Although there is a scarcity of evidence pertaining to the management of postoperative pain medication in the ambulatory setting, some findings suggest an approach similar to that used for the treatment of acute pain.
The Company states that in vivo tests have shown that the compound's pain suppressing efficacy is comparable to morphine.
The treatment is designed to deliver pain relief directly to the site of tissue injury, thereby potentially reducing the need for systemically administered pain medications.
Advanced practice providers were found to prescribe more opioids and in larger quantities compared with other physicians.
For patients undergoing cervical or lumbar spinal fusions, postoperative pain management with opioids is associated with higher postoperative pain scores and worse quality of life.
Patients undergoing surgery assume opioids will be most effective for postoperative pain relief, even if they don't expect to be prescribed opioids.
Hydrocodone's change from schedule III to schedule II in 2014 was associated with an increase in the amount of opioids filled in the initial prescription after surgery.
Patients undergoing robotic hysterectomy were found to report comparable pain scores when receiving celecoxib perioperatively or ketorolac postoperatively.
CA-008 is given as a single local injection and works by selectively desensitizing pain-conducting nerve fibers without causing numbness or weakness
Methadone vs desflurane as an adjunct to remifentanil may contribute to reducing perioperative opioid requirements in adolescents undergoing spinal surgery.
The integration of a Transitional Pain Service into a perioperative surgical home model could optimize perioperative pain control and opioid use, while reducing postdischarge hospital readmissions as well as the costs and disability linked to chronic postsurgical pain.
The Pain Sensitivity Questionnaire and Pain Catastrophizing Scale were found to be predictive of a chronically painful state in patients undergoing spine surgery in a comparable manner.
Variation exists in opioid prescribing practices among clinicians in single-hospital systems, which prompts concern about the potential for opioid overprescribing.
Women who undergo vaginal delivery in the United States may frequently be prescribed opioid medications for pain within 1 week of hospital discharge, often dispensed at high doses and in significant quantities.
Preoperative opioid use was reported by approximately 23% of patients undergoing surgery, with age, tobacco use, depression, poor life satisfaction, and medical comorbidities identified as independent factors associated with pre-interventional opioid use.
Postpartum Pain Management Recommendations From the American College of Obstetricians and Gynecologists
A committee from the American College of Obstetricians and Gynecologists formulated several recommendations for safely managing pain and fatigue in women during the early postpartum period.
Higher PainDETECT Scores, Neuropathic Pain Preoperatively May Increase Risk for Chronic Pain Post-TKR
Individuals with knee osteoarthritis who have indicators of high vs low/no levels of neuropathic pain may be at elevated risk for chronic pain after total knee replacement surgery.
Labor epidural analgesia may be associated with reduced likelihood of breastfeeding at 6 weeks.
The Company indicated that they will work towards an New Drug Application submission for the treatment in the second half of 2018.
For patients undergoing invasive procedures, opioid-related adverse drug events are common and are associated with worse clinical and cost outcomes.
The use of opioid-free analgesia to manage postsurgical pain is still limited, particularly in some patient groups that may be at a higher risk for opioid-related adverse drug events.
Administration of clonidine — intrathecally or intravenously — may not supplement spinal anesthesia-associated analgesia after cesarean delivery.
With the distinct qualities that come from post-surgical procedures in the realm of pediatrics, conclusions are still being considered.
Liposomal bupivacaine use in patients undergoing total knee arthroplasty is not associated with clinically meaningful reductions in inpatient opioid use, resource utilization, or opioid-related complications.
Perioperative lidocaine infusions may reduce the likelihood of developing chronic postsurgical pain.
Calcium phosphate cement loaded with bupivacaine vs ropivacaine may accelerate functional recovery after bone reconstruction surgery and maintain bone-filling properties.
Regional anesthesia is associated with a lower opioid consumption in both knee and hip replacement surgeries, compared to general anesthesia.
A once-daily intravenous injection of meloxicam may safely and effectively relieve moderate to severe bunionectomy-associated pain.
Adverse events associated with opioids administered for the management of postsurgical and postendoscopy pain may be associated with worse cost and patient outcomes.
In this multicenter, double-blind, placebo-controlled trial, patients (N=409) were randomized 1:1:1 to a postoperative regimen of IV tramadol 50mg, IV tramadol 25mg, or placebo administered over 15 minutes at hours 0, 2, 4, and once every 4 hours thereafter (up to 13 doses).
The management of postsurgical pain with patient-controlled analgesia pumps may be safe, as indicated by a low rate of device-related error.
Clinical Pain Advisor Articles
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- Seven-Item Pain Intensity Measure Reliable in Individuals With Dementia
- Initial Consultation for Neck Pain May Reduce Opioid Consumption, Healthcare Utilization
- FDA-Approved Test Provides Pharmacogenetic Reports Directly to Consumers
- Set of Interventions May Effectively Reduce Opioid Overprescribing
- Methamphetamine Use on the Rise in Patients With Opioid Use Disorder
- Two Screening Tools May Accurately Predict Transition From Acute to Chronic Low Back Pain
- Dozens of Medical Groups Join Forces to Improve Diagnoses
- FDA Grants Non-Opioid Analgesic VVZ-149 Fast Track Status
- Little to No Association Found Between Physician Performance and Medical School Ranking