An abuse liability assessment was conducted to determine the abuse potential and pharmacokinetics of extended-release vs immediate-release oxycodone.
Abuse-deterrent extended-release oxycodone (Xtampza® ER; Collegium Pharmaceutical) provided adequate pain relief for patients with chronic low back pain who were previously receiving immediate-release oxycodone.
Administration of abuse-deterrent formulations of immediate-release oxycodone and extended-release morphine leads to slower and lower absorption rates in nondependent recreational drug users compared with standard oxycodone and morphine formulations.
In hospitalized patients, tramadol use was shown to be associated with hypoglycemia.
About 20% of U.S. bariatric surgery patients are still using prescription opioids 7 years later.
A prescription weight-loss drug reduced the urge to use opiates like oxycodone.
Drug overdose deaths have nearly tripled in the United States since 1999, with the largest increases seen for whites and middle-aged Americans.
Chronic pain patients being treated with certain opioid and non-opioid medications had significantly lower serum concentrations of free testosterone and free estradiol.
The article reviews the epidemiology, clinical features, outcomes, prevention strategies, risk identification and management NAS.
The benefit-risk profile of oxycodone/naloxone was found to be noninferior compared to tapentadol, and oxycodone/naloxone demonstrated superior analgesic efficacy.
Clinical Pain Advisor Articles
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