Opioid Addiction

Patterns of Potential Misuse Help Assess Risk of Opioid Overdose

Patterns of Potential Misuse Help Assess Risk of Opioid Overdose

Researchers estimated how a range of patterns of potential opioid misuse relate to adverse outcomes during the next year.

Opioid Education Program Boosts PA Students' Confidence in Providing Patient Care

Opioid Education Program Boosts PA Students' Confidence in Providing Patient Care

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PA students perceived improved confidence in their ability to provide patient education and counseling.

Unit-Dose Packaging of Buprenorphine-Naloxone Effective on Unintentional Pediatric Exposure

Unit-Dose Packaging of Buprenorphine-Naloxone Effective on Unintentional Pediatric Exposure

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Unit-dose packaging of buprenorphine-naloxone was associated with a reduced number of unintentional exposures of young children presenting to poison centers.

Detox vs Medication-Assisted Treatment for Opioid Use Disorder in Pregnancy: Expert Roundtable

Detox vs Medication-Assisted Treatment for Opioid Use Disorder in Pregnancy: Expert Roundtable

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Based on current evidence, there is a strong consensus that medication-assisted treatment is recommended over detoxification in the treatment of opioid use disorder during pregnancy.

Naloxone Training Beneficial for PA Students

Naloxone Training Beneficial for PA Students

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Opioid-specific health seminars may help PA students learn lifesaving treatments to perform in the future.

Many Have Unused Opioids After Urologic Procedures

Many Have Unused Opioids After Urologic Procedures

Patients undergoing urological procedures use just over half of their initial prescription of opioids, on average.

Supervised Injection Sites Hailed as the Latest Strategy to Fight the Opioid Crisis

Supervised Injection Sites Hailed as the Latest Strategy to Fight the Opioid Crisis

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Although they are against the law, supervised injection sites are slated to open in Seattle, San Francisco, and Philadelphia in 2018.

First Non-Opioid Drug Approved for Managing Opioid Withdrawal Symptoms

First Non-Opioid Drug Approved for Managing Opioid Withdrawal Symptoms

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Lucemyra, a selective alpha 2-adrenergic receptor agonist, works by reducing the release of norepinephrine and decreasing sympathetic tone.

Opioid-Related Payments Linked to Increase in Opioid Prescriptions

Opioid-Related Payments Linked to Increase in Opioid Prescriptions

Researchers examined the extent to which pharmaceutical industry marketing of opioid products to physicians during 2014 correlated with opioid prescribing in 2015.

Lofexidine Effective for Opioid Withdrawal Symptoms

Lofexidine Effective for Opioid Withdrawal Symptoms

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Investigators pooled data from 2 phase 3 placebo-controlled studies to evaluate the safety and efficacy of lofexidine for opioid withdrawal symptoms.

Walmart Plans on Restricting Supply on Acute Opioid Prescription Fills

Walmart Plans on Restricting Supply on Acute Opioid Prescription Fills

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For states that currently limit new acute opioid prescription fills to <7 days, Walmart and Sam's Club pharmacies will follow that state law.

Methadone Maintenance Therapy Associated With Greater Access to Physician Care in HCV-Positive Drug Users

Methadone Maintenance Therapy Associated With Greater Access to Physician Care in HCV-Positive Drug Users

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The investigators suggest that enrollment in a methadone maintenance therapy program may be helpful in providing access to HCV care in people who inject drugs.

People With Opioid Use Disorder Have High Suicide Rate

People With Opioid Use Disorder Have High Suicide Rate

The researchers note that patients with chronic pain and those with mood disorders are more likely to receive opioid prescriptions and are also at greater risk for suicide.

Contribution of Synthetic Opioids to Drug Overdose Deaths

Contribution of Synthetic Opioids to Drug Overdose Deaths

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Opioids were the leading contributor to drug overdose deaths between 2015 and 2016.

Prenatal Exposure to Opiates, Illicit Substances Associated With ADHD, Autism in Offspring

Prenatal Exposure to Opiates, Illicit Substances Associated With ADHD, Autism in Offspring

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The results of this study suggest that children prenatally exposed to substances should receive early mental health assessment.

Pre-Op Chronic Opioid Use Ups Poor Outcomes Post Spinal Fusion

Pre-Op Chronic Opioid Use Ups Poor Outcomes Post Spinal Fusion

Preoperative chronic opioid use is associated with poor outcomes and continued dependence after posterior lumbar fusion.

FDA Issues Mandatory Recall of Food Products Containing Powdered Kratom

FDA Issues Mandatory Recall of Food Products Containing Powdered Kratom

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The recall is due to samples of the product testing positive for Salmonella.

Helping to End Addiction Long-Term Initiative by NIH Launched to Address Opioid Epidemic

Helping to End Addiction Long-Term Initiative by NIH Launched to Address Opioid Epidemic

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National Institutes of Health Director, Francis Collins, MD, PhD, announced on April 4, 2018 the launch of the Helping to End Addiction Long-Term Initiative.

Opioid Receipt Up for Teens With Mental Health Conditions

Opioid Receipt Up for Teens With Mental Health Conditions

Adolescents with pre-existing mental health conditions and treatments are more likely to receive any opioid and to transition to long-term opioid therapy.

Long-Term Opioid Use Increases Asthma, Allergic Rhinitis Prevalence

Long-Term Opioid Use Increases Asthma, Allergic Rhinitis Prevalence

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In addition to their analgesic effects, opioid binding to opioid receptors leads to the release of histamine from mast cells, including those implicated in asthma and allergic rhinitis.

Opioid Dependence Pharmacotherapy and Clinical, Criminal Outcomes in Mental Illness

Opioid Dependence Pharmacotherapy and Clinical, Criminal Outcomes in Mental Illness

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All 3 opioid-dependence pharmacotherapies — methadone, buprenorphine, and oral naltrexone — were associated with reductions in inpatient substance abuse treatment.

An Avenue for the Development of Opioid Adjuncts for Enhanced Analgesia, Reduced Abuse Potential

An Avenue for the Development of Opioid Adjuncts for Enhanced Analgesia, Reduced Abuse Potential

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Suppression of the function of an intracellular modulator of the μ-opioid receptor was found to enhance the analgesic activity of agonists for those receptors, delay the tolerance to morphine and reduce its rewarding effects

Antidepressant Medication Adherence and Long-Term Opioid Cessation

Antidepressant Medication Adherence and Long-Term Opioid Cessation

Antidepressant medication adherence is associated with cessation of long-term prescription opioid use among patients with non-cancer pain.

Opioid Use in Sepsis Linked to Higher Mortality

Opioid Use in Sepsis Linked to Higher Mortality

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Higher mortality associated with opioid use in hospitalized patients with sepsis suggests an immunosuppressive effect that could contribute to worse outcomes.

Opioid Prescribing Trends in the Veterans Health Administration

Opioid Prescribing Trends in the Veterans Health Administration

Opioid prescribing trends in the Veterans Health Administration from 2010 to 2016 followed similar trajectories as non-VHA settings, peaking around 2012 then declining.

Evaluating Excessive NSAID Use in Ibuprofen Users

Evaluating Excessive NSAID Use in Ibuprofen Users

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Fifteen percent of adults who took ibuprofen during a 1-week diary study exceeded the maximum recommended daily dose limit.

Electronic Medical Record "Nudge" May Shape Opioid Prescribing Behavior in the ED

Electronic Medical Record "Nudge" May Shape Opioid Prescribing Behavior in the ED

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Implementation of electronic medical record default opioid prescriptions of 10 tablets of 5 mg oxycodone/325 mg acetaminophen at discharge from the ED may be associated with an increased percentage of prescriptions for 10 tablets, compared with no default.

Opioid Prescriptions for Musculoskeletal Conditions Increase Patient Satisfaction

Opioid Prescriptions for Musculoskeletal Conditions Increase Patient Satisfaction

The researchers found that 13.1% of patients with musculoskeletal conditions were opioid users, and those using prescribed opioids were more likely to be highly satisfied with their care.

Efficacy of Tamper-Resistant Controlled-Release Oxycodone

Efficacy of Tamper-Resistant Controlled-Release Oxycodone

The tamper-resistant formulation of controlled-release oxycodone in Australia reduced tampering among high-risk populations.

FDA Tentatively Approves Arymo ER Label Update for Abuse-Deterrent Claims

FDA Tentatively Approves Arymo ER Label Update for Abuse-Deterrent Claims

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The FDA has tentatively approved an update to the Arymo ER extended-release tablets labeling to include data from an intranasal abuse-deterrent claim.

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