Opioid Addiction

Notifications by PDMPs May Not Effectively Reduce Opioid Misuse

Notifications by PDMPs May Not Effectively Reduce Opioid Misuse

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Unsolicited notices to prescribers as part of prescription drug monitoring programs may not effectively reduce opioid use, as patients may seek other prescribers.

Abuse-Deterrent Opioid Formulations: Barriers to Broader Use

Abuse-Deterrent Opioid Formulations: Barriers to Broader Use

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Abuse-deterrent opioid formulations have not yet been widely accepted despite their proposed value in reducing opioid abuse and related mortality. Many of the current barriers to broader use are related to their higher cost compared with conventional formulations.

Integrating Treatments for Opioid Use Disorder and Infectious Diseases

Integrating Treatments for Opioid Use Disorder and Infectious Diseases

All healthcare providers have a role in combating the opioid use disorder epidemic and its infectious disease consequences.

Which Opioids Are More Likely to Induce QT Interval Prolongation?

Which Opioids Are More Likely to Induce QT Interval Prolongation?

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Studies comparing MMT to buprenorphine maintenance treatment (BMT) over 5-years found buprenorphine to be a safer drug for opioid maintenance treatment as it had no significant effect on QT prolongation.

Assessing Medication-Assisted Treatments: FDA Guidance for Drug Developers

Assessing Medication-Assisted Treatments: FDA Guidance for Drug Developers

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In a communiqué issued on August 6, 2018, the US Food and Drug Administration announced the release of a draft guidance titled, "Opioid Use Disorder: Endpoints for Demonstrating Effectiveness of Drugs for Medication-Assisted Treatment - Guidance for Industry."

Opioid Use Disorders: Advances in Pharmacotherapy Provide Long-term Results

Opioid Use Disorders: Advances in Pharmacotherapy Provide Long-term Results

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Despite the availability of long-acting opioid antagonists, many patients with OUD never receive adequate treatment.

Lucemyra Now Available for Mitigation of Opioid Withdrawal Symptoms

Lucemyra Now Available for Mitigation of Opioid Withdrawal Symptoms

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Lucemyra is not indicated as a treatment for opioid use disorder.

Medicaid Expansion Under ACA Found to Benefit Access to Treatments for Opioid Use Disorder

Medicaid Expansion Under ACA Found to Benefit Access to Treatments for Opioid Use Disorder

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States that have adopted Medicaid expansions under the Affordable Care Act saw an increase in the utilization and availability of treatments for opioid use disorder.

Therapy Focusing on Mindfulness Improves Outcomes for Women With Substance Use Disorder

Therapy Focusing on Mindfulness Improves Outcomes for Women With Substance Use Disorder

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These findings are consistent with emerging neurocognitive models linking interoception to emotion regulation and related health outcomes, providing valuable input in improving substance use disorder treatment.

Debunking Myths Around Treatment for Opioid Use Disorder

Debunking Myths Around Treatment for Opioid Use Disorder

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Primary care office-based addiction treatment of opioid use disorder with buprenorphine is a realistic and scalable solution to address the overdose crisis in the United States.

Distress Tolerance Associated With Alcohol Use in Women With Opioid Use Disorder

Distress Tolerance Associated With Alcohol Use in Women With Opioid Use Disorder

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In women with opioid use disorder, greater distress tolerance may be associated with fewer alcohol use days.

Higher Buprenorphine Dose May Not Increase Severity of Neonatal Abstinence Syndrome

Higher Buprenorphine Dose May Not Increase Severity of Neonatal Abstinence Syndrome

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Pregnant women receiving medication therapy for addiction can be prescribed higher doses of buprenorphine without increasing the risk or severity of neonatal abstinence syndrome.

Preoperative Opioids Used by Nearly One-Quarter of Surgical Patients

Preoperative Opioids Used by Nearly One-Quarter of Surgical Patients

Preoperative opioid use is reported in 23.1 percent of patients undergoing surgery.

Prescribed Opioids Difficulties Scale Effective for Assessing Concerns of Patients With Chronic Pain

Prescribed Opioids Difficulties Scale Effective for Assessing Concerns of Patients With Chronic Pain

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The Prescribed Opioids Difficulties Scale may be effective for identifying patients using opioids for chronic noncancer pain who are worried about their usage.

NIH Initiative Aims to Address Opioid Misuse Over Long Term

NIH Initiative Aims to Address Opioid Misuse Over Long Term

A novel, innovative initiative is being developed to help end addiction over the long term, according to a viewpoint article published online June 12 in the Journal of the American Medical Association.

Rapid Decrease of Heroin Use During Opioid Substitution Treatment Associated With Treatment Success

Rapid Decrease of Heroin Use During Opioid Substitution Treatment Associated With Treatment Success

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In patients receiving opioid substitution treatment for opioid use disorder (mainly involving heroin), those exhibiting a rapid decline in heroin use were found to be more likely to have successful treatment outcomes.

Wearable Device Cleared for Use During Opioid Detoxification

Wearable Device Cleared for Use During Opioid Detoxification

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Electrical pulses are sent through small needles that are inserted in the ear to combat the early stages of detoxification, leading to stabilization.

Public Support Only Moderate for Opioid Harm Reduction Strategies

Public Support Only Moderate for Opioid Harm Reduction Strategies

Shame to those who use opioids are based on more evidence than what society perceives.

CDC Report: Integrating Tobacco Cessation Interventions in Mental Health, Substance Abuse Treatment Facilities

CDC Report: Integrating Tobacco Cessation Interventions in Mental Health, Substance Abuse Treatment Facilities

Providing barrier-free access to proven cessation treatments is critical to reduce smoking-related disease and death in the United States.

Recommendations for Perioperative Pain Management in Patients With Opioid Tolerance

Recommendations for Perioperative Pain Management in Patients With Opioid Tolerance

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With the increasing number of patients presenting to surgery with opioid tolerance, clinicians should be familiar with their specific analgesic needs.

Court-Mandated Substance Abuse Treatment: Exploring the Ethics and Efficacy

Court-Mandated Substance Abuse Treatment: Exploring the Ethics and Efficacy

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While many treatments for substance use disorder are not evidence based, several evidence-based approaches have shown effectiveness in court-mandated treatment settings.

Mandatory PDMP for Prescribers Lowers Opioid Dispensing Rate

Mandatory PDMP for Prescribers Lowers Opioid Dispensing Rate

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Legislation that requires prescribers to check Ohio's Prescription Drug Monitoring Program was found to lead to a reduction in the quantity of opioids and benzodiazepines dispensed.

FDA Cracks Down on Illegal Online Sales of Opioids

FDA Cracks Down on Illegal Online Sales of Opioids

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The U.S. Food and Drug Administration has issued warnings to 9 online companies selling illegal opioid medications on 53 websites, in direct violation of the Federal Food, Drug, and Cosmetic Act.

Studies ID Impact of U.S. Opioid-Related Mortality, Rx Patterns

Studies ID Impact of U.S. Opioid-Related Mortality, Rx Patterns

From 2001 to 2016 there was an increase in the number and percentage of opioid-related deaths; in addition, most patients receiving opioids receive immediate-release formulations.

NDA for First-of-Its-Kind Opioid Analgesic Submitted to FDA

NDA for First-of-Its-Kind Opioid Analgesic Submitted to FDA

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NKTR-181 is a long-acting selective full mu-opioid agonist.

Substance Abuse and Primary Psychosis: A Closer Look

Substance Abuse and Primary Psychosis: A Closer Look

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Patients will still be at risk for schizophrenia or bipolar disorder even several years after an episode of substance-induced psychosis.

Opioid Epidemic Associated With Increase in Recovery of Organs for Transplantation

Opioid Epidemic Associated With Increase in Recovery of Organs for Transplantation

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The number of transplants of organs from brain-dead donors has risen sharply in the United States, primarily due to the increase in mortality associated with the drug-abuse epidemic.

Two Lots of Naloxone Hydrochloride Carpuject Injections Recalled

Two Lots of Naloxone Hydrochloride Carpuject Injections Recalled

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Two lots of naloxone hydrochloride injections, USP have been recalled by Hospira, Inc., due to concerns regarding the presence of particulates on the syringe plunger.

Increases in Acute HCV Infection, Injection Drug Use, and the Opioid Epidemic

Increases in Acute HCV Infection, Injection Drug Use, and the Opioid Epidemic

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Investigators compared rates of opioid injection drug use with the incidence of acute HCV infection in the United States.

Years of Life Lost and Fatal Drug Overdoses

Years of Life Lost and Fatal Drug Overdoses

Researchers used vital statistics data to examine whether increases in mortality rates and years of potential life lost among midlife non-Hispanic whites from 1999 to 2015 are associated with increases in fatal overdoses.

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