Generic Name and Formulations:
Estrone sodium sulfate (as estropipate) 0.625mg, 1.25mg, 2.5mg; scored tabs.
Indications for OGEN:
Moderate to severe vasomotor symptoms of menopause. Atrophic vaginitis. Osteoporosis prevention. Hypoestrogenism.
Menopause: 0.625–5mg daily, given cyclically (3 weeks on, 1 week off). Osteoporosis prevention (begin therapy soon after menopause): 0.625mg daily, given cyclically (25 days of a 31-day cycle). Hypoestrogenism: 1.25–7.5mg daily for 3 weeks. Repeat course if withdrawal bleeding does not occur within 8–10 days after discontinuing. See literature. Reevaluate periodically.
Breast or estrogen-dependent carcinoma. Undiagnosed abnormal genital bleeding. Thromboembolic disorders. Thrombophlebitis. Pregnancy (Cat.X).
Patients with an intact uterus should almost always receive a progestin to avoid endometrial hyperplasia. Cardiovascular disease. Hepatic dysfunction. Gallbladder disease. Conditions aggravated by fluid retention. Bone disease associated with hypercalcemia. Do initial complete physical and repeat annually (include BP, mammogram, and PAP smear). Discontinue if jaundice or hypertension occurs and at least 2 weeks before surgery associated with thromboembolism. Nursing mothers.
See literature. GI upset, breakthrough bleeding, edema, weight changes, mastodynia, hypertension, intolerance to contact lenses.
Clinical Pain Advisor Articles
- Brain Plasticity in Patients With Complex Regional Pain Syndrome
- Perturbation-Based Rehabilitation Effective for Chronic Low Back Pain
- IBS-Associated Chronic Pain: Formulation of Core Diagnostic Criteria
- Fluoroscopically Guided Sacroiliac Interventions: Appropriate Use Criteria
- Cannabis Use Associated With Relationship Between Pain and Negative Affect
- Cannabis Use Associated With Aberrant Drug Behaviors
- Walgreens to Carry Naloxone in All Pharmacies to Combat Drug Abuse
- Independent Pharmacies Expanding Services Available to Patients
- Ketamine Exhibits Effective Pain Relief for Refractory Headaches
- Pain In Elite Athletes: IOC Recommendations on Contributing Factors and Treatment Approach
- Naproxen Plus Muscle Relaxants vs Naproxen Monotherapy for Low Back Pain
- Pain Processing: Examining the Role of Oxytocin
- Short- vs Long-Acting Opioids for Osteoarthritis Pain
- Extended-Release Naltrexone Injections Reduce Opioid Dependence
- Depressive Symptoms in Medical Interns Increased With Work-Family Conflicts