This activity is provided by Paradigm Medical Communications, LLC.
This activity is supported by an educational grant from Pfizer Inc.
Rheumatoid arthritis (RA) is the most common inflammatory arthritis in adults. Janus kinases (JAKs) are central to the destructive immune and inflammatory responses implicated in the pathogenesis of RA. In this activity, the expert faculty, Dr. Roy Fleischmann, Dr. Allan Gibofsky and Dr. Joseph Markenson, will provide a primer on the role of JAKs in the pathophysiology of RA and the clinical use of JAK inhibitors.
You will have an opportunity to test your knowledge of JAKs, JAK inhibitors, and their use in the treatment of RA in the interactive “Do You Know JAK?” game. The object of the game is to successfully inhibit the progress of RA through correctly answering questions about the disease, the inflammatory pathways, and therapeutic options for treatment. Correct answers will result in successful JAK inhibition and reduction of inflammation, while incorrect answers will show no change. These exercises will be followed by a roundtable discussion with the faculty highlighting the unique features of JAK inhibition in RA.
This activity has been designed to address the educational needs of physicians specializing in rheumatology. It may also benefit nurses, nurse practitioners, PAs, and other members of the multidisciplinary team who care for patients with RA.
Upon proper completion of this activity, participants should be better able to:
Describe the role of Janus kinase (JAK) in the chronic cycle of inflammation associated with RA
Identify the intracellular immune and anti-inflammatory effects of JAK inhibition on RA
Select appropriate candidates for treatment of RA with JAK inhibitors
Conflict Of Interest Disclosure Policy
Paradigm Medical Communications, LLC, has implemented a system to resolve conflicts of interest for each CME activity to help ensure content objectivity, independence, fair balance, and that the content is aligned with the interest of the public. Conflicts, if any, are resolved through one or more processes. All CME content in this activity was independently reviewed to ensure that it is free of commercial bias, scientifically rigorous, aligned with the public interest, and compliant with all regulatory guidance and the ACCME’s Standards for Commercial Support of Continuing Medical Education.
The faculty reported the following financial relationships or relationships to products or devices, they or their spouses/life partners have with commercial interests related to the content of this CME activity:
Roy Fleischmann, MD, MACR Clinical Professor of Medicine University of Texas Southwestern Medical Center Co-Medical Director Metroplex Clinical Research Center Dallas, TX
Dr. Fleischmann discloses the following: Advisory Boards: AbbVie Inc., Eli Lilly and Company, Pfizer Inc. Speakers' Bureau: Pfizer Inc. Clinical Trials: AbbVie Inc., Eli Lilly and Company, Pfizer Inc.
Allan Gibofsky, MD, JD, MACR, FACP, FCLM Professor of Medicine, Healthcare Policy and Research Weill Medical College of Cornell University Attending Rheumatologist Hospital for Special Surgery New York, NY
Dr. Gibofsky discloses the following: Consulting Fees: AbbVie Inc., Eli Lilly and Company, Merck & Co., Inc, Pfizer Inc Speakers' Bureau: AbbVie Inc., Celgene Corporation, Horizon Pharma plc, Novartis Pharmaceuticals Corporation, Pfizer Inc Stockholder (Self and Spouse): AbbVie Inc., Amgen Inc, Bristol-Myers Squibb Company, Johnson & Johnson Services, Inc., Pfizer Inc, Regeneron Pharmaceuticals, Inc
Joseph A. Markenson, MD, MACP, FACP Clinical Professor of Medicine Weill Medical College of Cornell University Attending Rheumatologist Hospital for Special Surgery New York, NY
Dr. Markenson discloses the following: Consulting Fees: Celgene Corporation Eli Lilly and Company, Merck & Co., Inc Fees for non-CME Services: Bristol-Myers Squibb Company, Celgene Corporation, Eli Lilly and Company, Janssen Pharmaceuticals, Inc, Merck & Co., Inc, Pfizer Inc
Accredited Provider Disclosure
Paradigm Medical Communications, LLC, staff members have no financial relationships to disclose.
AMA PRA Category 1 Credit(s)TM
Paradigm Medical Communications, LLC, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
Paradigm Medical Communications, LLC, designates this enduring material for a maximum of 1.00 AMA PRA Category 1 CreditTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Additional Credit Information
PA Continuing Education AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 CreditTM from organizations accredited by ACCME or a recognized state medical society. PAs may receive a maximum of 1.00 Category 1 credits for completing this activity.
Nurse Practitioner Continuing Education The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 CreditTM from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA.
This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.
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As an ACCME-accredited provider, Paradigm Medical Communications, LLC, activities must include a balanced view of therapeutic options. Use of generic names contributes to this impartiality. The use of trade names should not be viewed as an endorsement of specific products by Paradigm Medical Communications, LLC.
To receive a CME certificate of participation, you should:
Follow the "Start Activity" button to go to the Paradigm Medical Communications website, where you will complete the pretest.
View the online activity in its entirety.
Complete and submit the online post-test and evaluation. You must answer 70% of the post-test questions correctly to earn credit. You will have unlimited opportunities to successfully complete the post-test.
A certificate of participation will be available for download/printing immediately following your successful completion of the post-test and evaluation. Your certificate will be saved on the Paradigm Medical Communications website and will not be available in your myCME CME History.
There is no fee required for participation in this activity.
For questions regarding CME credit, contact the Paradigm CME Department at (845) 398-5949.
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