Neuropathic Pain

Reviewing the Effectiveness of Lidocaine for the Management of Chronic Pain

Reviewing the Effectiveness of Lidocaine for the Management of Chronic Pain

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Systemic lidocaine administered via IV or patch has consistently shown effectiveness for the treatment and prevention of chronic pain.

Neuropathic Pain Common in End-Stage Knee, Hip Osteoarthritis

Neuropathic Pain Common in End-Stage Knee, Hip Osteoarthritis

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Patients with end-stage knee or hip osteoarthritis were found to often experience possible neuropathic pain - particularly pain at rest vs on activity, and in men.

Updated Criteria for CRPS Diagnosis May Reveal Presence of Neuropathic Pain After TKA

Updated Criteria for CRPS Diagnosis May Reveal Presence of Neuropathic Pain After TKA

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Use of the 2006 vs 2007 criteria for the diagnosis of complex regional pain syndrome may lead to the misdiagnosis of patients experiencing unexplained excessive pain after total knee arthroplasty.

New Guidelines for Opioid Use in Refractory Restless Leg Syndrome

New Guidelines for Opioid Use in Refractory Restless Leg Syndrome

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Opioids may be "life-transforming" for patients with refractory restless legs syndrome when taken in relatively low total daily doses, according to new guidelines.

Limited Evidence for the Effectiveness of Oxcarbazepine in Neuropathic Pain

Limited Evidence for the Effectiveness of Oxcarbazepine in Neuropathic Pain

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Evidence for the effectiveness of oxcarbazepine in painful diabetic neuropathy and other forms of neuropathic pain is limited.

Capsaicin Patch Superior to Pregabalin for Alleviating, Resolving Dynamic Mechanical Allodynia

Capsaicin Patch Superior to Pregabalin for Alleviating, Resolving Dynamic Mechanical Allodynia

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Treatment with the capsaicin 8% patch Qutenza may be more effective than pregabalin for reducing the intensity and area of dynamic mechanical allodynia and for complete resolution of the disorder.

Chronic Pain in Pachyonychia Congenita May Have Neuropathic Origin

Chronic Pain in Pachyonychia Congenita May Have Neuropathic Origin

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Chronic pain experienced by patients with pachyonychia congenita may be caused by damage to the peripheral nerve fibers, with the hyperalgesia and allodynia observed in affected regions likely to be manifestations of peripheral sensitization.

Peripheral Nerve Stimulation May Provide Long-Term Pain Relief for Leprosy-Related Mononeuropathy

Peripheral Nerve Stimulation May Provide Long-Term Pain Relief for Leprosy-Related Mononeuropathy

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Peripheral nerve stimulation may provide long-term pain relief in patients with painful mononeuropathy secondary to leprosy.

Spinal Cord Stimulation Reduces Pain Associated With Diabetic Polyneuropathy

Spinal Cord Stimulation Reduces Pain Associated With Diabetic Polyneuropathy

After 5 years, 55% of patients had experienced treatment success and 80% of patients with a permanent implant still used their SCS device.

Pain in Elite Athletes: IOC Recommendations on Contributing Factors and Treatment Approach

Pain in Elite Athletes: IOC Recommendations on Contributing Factors and Treatment Approach

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Pain management in athletes requires a clear understanding of the different types of pain and various factors that can contribute to pain in this population.

Virtual Reality Effective on Spinal Cord Injury-Related Chronic Neuropathic Pain

Virtual Reality Effective on Spinal Cord Injury-Related Chronic Neuropathic Pain

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The use of virtual reality (VR) and multisensory stimulation in patients with spinal cord injury promotes mild relief from chronic neuropathic pain and represents a potentially helpful addition to SCI neurorehabilitation management.

Hypoalgesia, Hyperalgesia Linked to Multiple Sclerosis Lesion Location

Hypoalgesia, Hyperalgesia Linked to Multiple Sclerosis Lesion Location

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In patients with multiple sclerosis, lesions in the right dorsolateral prefrontal cortex and posterior periventricular area may be associated with hypo and hyperalgesia.

Dronabinol Safe and Effective for Neuropathic Pain Associated With Multiple Sclerosis

Dronabinol Safe and Effective for Neuropathic Pain Associated With Multiple Sclerosis

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Dronabinol provides a safe and effective treatment option for patients with symptoms of neuropathic pain associated with multiple sclerosis.

Peripheral Nerve Surgery for Burn Survivors: Improving Outcomes Through Clinician Self-Analysis

Peripheral Nerve Surgery for Burn Survivors: Improving Outcomes Through Clinician Self-Analysis

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As survival rates for patients with burns have improved, the need for effective treatments for chronic pain in this population has become more pressing.

Chemotherapy-Induced Peripheral Neuropathy: Mechanism Identified

Chemotherapy-Induced Peripheral Neuropathy: Mechanism Identified

The researchers found that paclitaxel triggers CIPN by altering IP3 receptor phosphorylation and intracellular calcium flux and activating calcium-dependent calpain proteases.

Acupuncture for Chronic Pain Relief in Military Populations

Acupuncture for Chronic Pain Relief in Military Populations

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Electrical stimulation and a higher baseline pain score were shown to be associated with a higher chance of improved pain relief with acupuncture.

Neuroinflammation in Neuropathic Pain Indicated by Elevated Levels of Proinflammatory Chemokines in CSF

Neuroinflammation in Neuropathic Pain Indicated by Elevated Levels of Proinflammatory Chemokines in CSF

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Patients with neuropathic pain have elevated levels of a set of pro-inflammatory chemokines compared with healthy individuals, suggesting ongoing neuroinflammation.

Neuropathy Associated With Adjuvant Chemotherapy: Characteristics

Neuropathy Associated With Adjuvant Chemotherapy: Characteristics

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Chronic pain following adjuvant chemotherapy with docetaxel or oxaliplatin may be solely account for by pure sensory neuropathy.

Opioid, Gabapentin Combo Rx May Increase Mortality Risk

Opioid, Gabapentin Combo Rx May Increase Mortality Risk

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Both gabapentin and opioids are commonly prescribed for the treatment of pain, making the likelihood of these two agents being prescribed together high.

FDA Approves New Treatment for Diabetic Peripheral Neuropathy, Postherpetic Neuralgia

FDA Approves New Treatment for Diabetic Peripheral Neuropathy, Postherpetic Neuralgia

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The FDA has approved Lyrica CR, a once-daily treatment for the management of neuropathic pain associated with diabetic peripheral neuropathy and the management of postherpetic neuralgia.

Capsaicin 8% Patch Safe for Peripheral Neuropathic Pain

Capsaicin 8% Patch Safe for Peripheral Neuropathic Pain

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The use of capsaicin 8% patch repeat treatment is well tolerated and may provide effective long-term benefit in patients with peripheral neuropathic pain.

Chemo-Induced Peripheral Neuropathy Risk Reduced With Multivitamin

Chemo-Induced Peripheral Neuropathy Risk Reduced With Multivitamin

Multivitamin use before diagnosis of breast cancer is associated with reduced risk of symptoms of chemotherapy-induced peripheral neuropathy.

Cannabis for Neuropathic Pain: What Evidence Is There?

Cannabis for Neuropathic Pain: What Evidence Is There?

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There is currently little conclusive evidence to suggest a benefit of cannabis use for the management of neuropathic pain.

Gabapentin, Pregabalin Effective for Burn-Related Pruritus, Neuropathic Pain

Gabapentin, Pregabalin Effective for Burn-Related Pruritus, Neuropathic Pain

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The use of gabapentin, pregabalin, or both is effective for reducing pruritus and neuropathic pain in burn survivors.

Pregabalin vs Gabapentin for Neuropathic Pain to Achieve Therapeutic Dose

Pregabalin vs Gabapentin for Neuropathic Pain to Achieve Therapeutic Dose

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Patients with neuropathic pain are more likely to achieve effective therapeutic dose when treated with pregabalin compared with gabapentin.

Vitamin D Deficiency Associated With Neuropathic Pain in Rheumatoid Arthritis

Vitamin D Deficiency Associated With Neuropathic Pain in Rheumatoid Arthritis

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In patients with rheumatoid arthritis, vitamin D deficiency was shown to be associated with increased neuropathic pain.

Preemptive Analgesia to Prevent Chronic Postsurgical Pain

Preemptive Analgesia to Prevent Chronic Postsurgical Pain

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Preemptive analgesia seeks to prevent central sensitization and ensuing chronic pain, a concept that has shown promising results in preliminary studies.

Intravenous Lidocaine Safe, Effective for Chronic Pain

Intravenous Lidocaine Safe, Effective for Chronic Pain

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Lidocaine infusions were shown to provide long-lasting and adequate analgesia in 41% of patients with chronic pain.

Neuropathic Pain: Assessing Safety, Efficacy of Higher Pregabalin Doses

Neuropathic Pain: Assessing Safety, Efficacy of Higher Pregabalin Doses

Patients with neuropathic pain who do not respond to a low dose of pregabalin can benefit from a higher dose.

Neuropathic Pain Medications

Chart with medications used to treat neuropathic pain, including diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia.

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