Neuropathic Pain

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Neuropathy Associated With Adjuvant Chemotherapy: Characteristics

Neuropathy Associated With Adjuvant Chemotherapy: Characteristics

Chronic pain following adjuvant chemotherapy with docetaxel or oxaliplatin may be solely account for by pure sensory neuropathy.

Neuroinflammation in Neuropathic Pain Indicated by Elevated Levels of Proinflammatory Chemokines in CSF

Neuroinflammation in Neuropathic Pain Indicated by Elevated Levels of Proinflammatory Chemokines in CSF

Patients with neuropathic pain have elevated levels of a set of pro-inflammatory chemokines compared with healthy individuals, suggesting ongoing neuroinflammation.

FDA Approves New Treatment for Diabetic Peripheral Neuropathy, Postherpetic Neuralgia

FDA Approves New Treatment for Diabetic Peripheral Neuropathy, Postherpetic Neuralgia

The FDA has approved Lyrica CR, a once-daily treatment for the management of neuropathic pain associated with diabetic peripheral neuropathy and the management of postherpetic neuralgia.

Opioid, Gabapentin Combo Rx May Increase Mortality Risk

Opioid, Gabapentin Combo Rx May Increase Mortality Risk

Both gabapentin and opioids are commonly prescribed for the treatment of pain, making the likelihood of these two agents being prescribed together high.

Chronic Inflammatory Demyelinating Polyneuropathy: Privigen Gains FDA Approval

Chronic Inflammatory Demyelinating Polyneuropathy: Privigen Gains FDA Approval

Privigen is stabilized with proline, which has been shown to reduce IgG aggregation and dimer formation.

Capsaicin 8% Patch Safe for Peripheral Neuropathic Pain

Capsaicin 8% Patch Safe for Peripheral Neuropathic Pain

The use of capsaicin 8% patch repeat treatment is well tolerated and may provide effective long-term benefit in patients with peripheral neuropathic pain.

Chemo-Induced Peripheral Neuropathy Risk Reduced With Multivitamin

Chemo-Induced Peripheral Neuropathy Risk Reduced With Multivitamin

Multivitamin use before diagnosis of breast cancer is associated with reduced risk of symptoms of chemotherapy-induced peripheral neuropathy.

Cannabis for Neuropathic Pain: What Evidence Is There?

Cannabis for Neuropathic Pain: What Evidence Is There?

There is currently little conclusive evidence to suggest a benefit of cannabis use for the management of neuropathic pain.

Gabapentin, Pregabalin Effective for Burn-Related Pruritus, Neuropathic Pain

Gabapentin, Pregabalin Effective for Burn-Related Pruritus, Neuropathic Pain

The use of gabapentin, pregabalin, or both is effective for reducing pruritus and neuropathic pain in burn survivors.

Pregabalin vs Gabapentin for Neuropathic Pain to Achieve Therapeutic Dose

Pregabalin vs Gabapentin for Neuropathic Pain to Achieve Therapeutic Dose

Patients with neuropathic pain are more likely to achieve effective therapeutic dose when treated with pregabalin compared with gabapentin.

Vitamin D Deficiency Associated With Neuropathic Pain in Rheumatoid Arthritis

Vitamin D Deficiency Associated With Neuropathic Pain in Rheumatoid Arthritis

In patients with rheumatoid arthritis, vitamin D deficiency was shown to be associated with increased neuropathic pain.

Preemptive Analgesia to Prevent Chronic Postsurgical Pain

Preemptive Analgesia to Prevent Chronic Postsurgical Pain

Preemptive analgesia seeks to prevent central sensitization and ensuing chronic pain, a concept that has shown promising results in preliminary studies.

Is Nerve Decompression Effective for Restless Leg Syndrome?

Is Nerve Decompression Effective for Restless Leg Syndrome?

Nerve decompression used to treat peripheral neuropathy may improve symptoms of restless leg syndrome.

Intravenous Lidocaine Safe, Effective for Chronic Pain

Intravenous Lidocaine Safe, Effective for Chronic Pain

Lidocaine infusions were shown to provide long-lasting and adequate analgesia in 41% of patients with chronic pain.

Neuropathic Pain: Assessing Safety, Efficacy of Higher Pregabalin Doses

Neuropathic Pain: Assessing Safety, Efficacy of Higher Pregabalin Doses

Patients with neuropathic pain who do not respond to a low dose of pregabalin can benefit from a higher dose.

Long-Term Opioid Therapy Linked to Adverse Effects in Polyneuropathy

Long-Term Opioid Therapy Linked to Adverse Effects in Polyneuropathy

Long-term treatment with opioids is associated with more adverse outcomes in patients with polyneuropathy, including depression, overdose, and opioid dependence.

Peripheral Nerve Stimulation Effective for Chronic Pain With Postherpetic Neuralgia

Peripheral Nerve Stimulation Effective for Chronic Pain With Postherpetic Neuralgia

Researchers observed a reduction in pain score in a patient using wireless peripheral nerve stimulation for chronic pain secondary to postherpetic neuralgia.

Neuropathic Pain Medications

Chart with medications used to treat neuropathic pain, including diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia.

Updated Diagnostic Criteria for Neuropathic Pain in SCI, Stroke, MS

Updated Diagnostic Criteria for Neuropathic Pain in SCI, Stroke, MS

The diagnostic criteria formulated by the ACTTION-APS Pain Taxonomy working group focus on neuropathic pain from SCI, stroke, and MS.

Orexin Receptor Antagonist Ineffective on Painful Diabetic Neuropathy

Orexin Receptor Antagonist Ineffective on Painful Diabetic Neuropathy

Filorexant is not effective in relieving painful diabetic neuropathy-related pain.

Neuropathic Pain in Low Back-Related Leg Pain: the State of Evidence

Neuropathic Pain in Low Back-Related Leg Pain: the State of Evidence

A systematic review points to a dearth of evidence regarding the neuropathic etiology of low back-related leg pain.

Current State of Evidence on Ketamine: Uses, Effects, Research

Current State of Evidence on Ketamine: Uses, Effects, Research

Ketamine was found to alleviate several pain modalities, and a number of clinical trials investigating its efficacy are ongoing.

Gabapentin Assessed in Chronic Neuropathic Pain

Gabapentin Assessed in Chronic Neuropathic Pain

Gabapentin, at doses of 1800 mg to 3600 mg can provide "good levels of pain relief" to some individuals suffering from postherpetic neuralgia and peripheral diabetic neuropathy.

Cannabinoids May Provide Limited Relief From Neuropathic Pain

Cannabinoids May Provide Limited Relief From Neuropathic Pain

Selective cannabinoids may provide limited relief from chronic neuropathic pain and improvements in quality of life and sleep.

Association Between Osteoporosis and Multiple Sclerosis

Association Between Osteoporosis and Multiple Sclerosis

Patients with multiple sclerosis (MS) have lower bone mineral density and greater rates of osteoporosis than healthy controls.

Long-Term Opioids Associated With Worse Functional Status, Adverse Events in Polyneuropathy

Long-Term Opioids Associated With Worse Functional Status, Adverse Events in Polyneuropathy

Polyneuropathy may increase the likelihood of patients receiving long-term opioid therapy.

Genetic Variant Tied to Systemic Lupus Identified

Genetic Variant Tied to Systemic Lupus Identified

A genetic variant that is associated with both multiple sclerosis and systemic lupus erythematosus has been identified.

Trigeminal Neuralgia: Assessing Treatment Patterns to Improve Outcomes

Trigeminal Neuralgia: Assessing Treatment Patterns to Improve Outcomes

In a 3-year period, 45% of patients with trigeminal neuralgia received at least 3 unique treatments.

Cibinetide for the Treatment of Sarcoidosis

Cibinetide for the Treatment of Sarcoidosis

Cibinetide, an innate repair receptor agonist, was shown to exert disease-modifying effects by reversing sarcoidosis-related nerve loss in the cornea and skin.

Bortezomib-Induced Neuropathy From First to Second Treatment for Multiple Myeloma

Bortezomib-Induced Neuropathy From First to Second Treatment for Multiple Myeloma

Bortezomib-induced peripheral neuropathy does not worsen between initial treatment and retreatment in patients with multiple myeloma.