Neuropathic Pain

Latest

Preclinical Pain as a Marker for Amyotrophic Lateral Sclerosis

Preclinical Pain as a Marker for Amyotrophic Lateral Sclerosis

Pain is far more common and widespread in ALS than previously suspected, and initial pain symptoms may predate the clinical onset of the disease's hallmark motor dysfunction by as much as 2 years.

Ketamine for Refractory Neuropathic Pain

Ketamine for Refractory Neuropathic Pain

A ketamine regimen is superior to methadone, or ketamine combined with methadone, in alleviating neuropathic pain and associated sensory changes.

Is Opioid-Induced Hyperalgesia Lessened by Switching to Buprenorphine?

Is Opioid-Induced Hyperalgesia Lessened by Switching to Buprenorphine?

Changes in several measures of pain in patients suspected of opioid-induced hyperalgesia were observed after transitioning from opioids to buprenorphine.

Drugs Effective on Diabetic Peripheral Neuropathy-Related Pain

Drugs Effective on Diabetic Peripheral Neuropathy-Related Pain

Several classes of drugs reduce neuropathy-related pain better than placebo.

DRG Stimulation Superior to Spinal Cord Stimulation for Lower Extremity Pain

DRG Stimulation Superior to Spinal Cord Stimulation for Lower Extremity Pain

Dorsal root ganglion stimulation is more likely than spinal cord stimulation to provide pain relief in patients with neuropathic pain conditions affecting the lower extremities.

Pregabalin for Sciatica: Is It Effective?

Pregabalin for Sciatica: Is It Effective?

In patients with sciatica pain, treatment with pregabalin did not significantly reduce pain intensity compared with placebo.

Neuropathic Pain Complexity Requires Thoughtful Approach and Combination of Interventions

Neuropathic Pain Complexity Requires Thoughtful Approach and Combination of Interventions

The wide range of etiologies underlying neuropathic pain render it a particularly challenging condition to manage.

Central Neuropathic Pain Syndromes

Central Neuropathic Pain Syndromes

Differentiating central neuropathic pain from musculoskeletal or peripheral neuropathic pain can be challenging.

Diabetic Neuropathy: Updated Position Statement by the American Diabetes Association

Diabetic Neuropathy: Updated Position Statement by the American Diabetes Association

The American Diabetes Association released an updated position statement on the prevention, detection, and management of diabetic neuropathies.

Optic Neuritis RENEW Trial Results

Optic Neuritis RENEW Trial Results

The human monoclonal antibody opicinumab may potentially enhance spontaneous remyelination after acute optic neuritis.

Neurofeedback for Chemotherapy-induced Peripheral Neuropathy

Neurofeedback for Chemotherapy-induced Peripheral Neuropathy

Patients in the neurofeedback group reported significant declines in CIPN symptoms, compared with patients who did not get neurofeedback training.

Optimal Management of Post-mastectomy Pain Syndrome

Optimal Management of Post-mastectomy Pain Syndrome

Limited data suggest antidepressants, topical capsaicin, and fat grafting may reduce pain associated with post-mastectomy pain syndrome, but more and better studies are needed to determine optimal management for this debilitating condition.

Risks Associated With Neuropathic Pain Treatment

Risks Associated With Neuropathic Pain Treatment

Death and serious outcomes resulting from overdose or poisoning from drugs used to treat depression more than doubled during the last decade and a half, found a recent study, with amitriptyline topping the list.

Viewing Photographs Reduces Pain Ratings in Patients With Chronic Pain

Viewing Photographs Reduces Pain Ratings in Patients With Chronic Pain

Viewing photographs can decrease pain intensity in patients with chronic pain.

Proliferative Diabetic Retinopathy: Outcomes With Ranibizumab vs Panretinal Photocoagulation

Proliferative Diabetic Retinopathy: Outcomes With Ranibizumab vs Panretinal Photocoagulation

Cumulative probability of proliferative diabetic retinopathy worsening was 42% in the panretinal photocoagulation group vs 34% in the ranibizumab group.

Classification of Peripheral Neuropathic Pain Based on Sensory Profiles

Classification of Peripheral Neuropathic Pain Based on Sensory Profiles

Researchers identified 3 subgroups of patients with peripheral neuropathic pain, based on sensory signs and symptoms.

Safety, Efficacy of Nonparticulate and Particulate Corticosteroids in Epidural Injections

Safety, Efficacy of Nonparticulate and Particulate Corticosteroids in Epidural Injections

Similar efficacy, superior safety of nonparticulate vs particulate corticosteroids for alleviating radicular pain.

Assessing Pregabalin Efficacy With Concomitant Neuropathic Pain Medications

Assessing Pregabalin Efficacy With Concomitant Neuropathic Pain Medications

The therapeutic efficacy of pregabalin in treating 2 types neuropathic pain (NeP) is not influenced by concomitant NeP medications.

Risk Factor Analysis for Severe Dry Eye Symptoms

Risk Factor Analysis for Severe Dry Eye Symptoms

Pain perception and severity are important when evaluating and managing dry eye.

Targeted Steroid Injection Via Epidural Catheter vs Standard C7-T1 Approach for Radicular Pain

Targeted Steroid Injection Via Epidural Catheter vs Standard C7-T1 Approach for Radicular Pain

Transforaminal approach to the treatment of cervical radicular pain presents risks.

Toward a New Class of Analgesics for Neuropathic Pain

Toward a New Class of Analgesics for Neuropathic Pain

Recent findings offer a new avenue for the development of peripheral analgesics with minimal adverse effects.

Risk Factors for Polyneuropathy

Risk Factors for Polyneuropathy

Diabetes, prediabetes, and obesity may be metabolic drivers of polyneuropathy.

Costs of Pregabalin vs Gabapentin for Peripheral Neuropathic Pain

Costs of Pregabalin vs Gabapentin for Peripheral Neuropathic Pain

Lower cost for pregabalin Tx due to lower use of concomitant medications, fewer primary care visits, and fewer days of sick leave.

Proposed Algorithm to Diagnose, Treat Neuropathic Pain

Proposed Algorithm to Diagnose, Treat Neuropathic Pain

A research group developed the algorithm through a year-long process of reviewing data, sharing their own clinical experiences, and considering feedback from geriatric and pain societies.

Chinese Herb Shows Antinociceptive Effects on Neuropathic Pain

Chinese Herb Shows Antinociceptive Effects on Neuropathic Pain

YHS presents a potential new treatment option for neuropathic pain management, without the tolerance observed with many analgesic drugs.

Pregabalin Also Effective for Established Neuropathic Pain

Pregabalin Also Effective for Established Neuropathic Pain

In all patients together, pregabalin significantly improved pain score at end point versus placebo; similar results were seen in each pain duration category.

Parkinson's Intestinal Gel May Cause Neuropathic Pain

Parkinson's Intestinal Gel May Cause Neuropathic Pain

Participants in the LCIG group demonstrated improved PD symptoms and quality of life compared to the other groups, but several cases of denervation and increased thermal thresholds were observed in patients treated with LCIG.

Efficacy of Transdermal Analgesic in Reducing Pain Scores, Opioid Use

Efficacy of Transdermal Analgesic in Reducing Pain Scores, Opioid Use

Preliminary results suggest that this transdermal analgesic is efficacious in reducing opioid use and pain scores in patients experiencing chronic neuropathy and musculoskeletal pain.

Updated Guidelines on Neurostimulation for Chronic Pain by the European Academy of Neurology

Updated Guidelines on Neurostimulation for Chronic Pain by the European Academy of Neurology

The lack of evidence base for treating chronic pain with neurostimulation resulted in the development of guideline recommendations based on systematic review and meta-analysis of published studies.

Neurofeedback for Neuropathic Pain

Neurofeedback for Neuropathic Pain

The most successful intervention -as assessed by largest reduction of CNP-associated theta bands- was achieved with motor imagination of feet.