Neuropathic Pain

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Peripheral Nerve Surgery for Burn Survivors: Improving Outcomes Through Clinician Self-Analysis

Peripheral Nerve Surgery for Burn Survivors: Improving Outcomes Through Clinician Self-Analysis

As survival rates for patients with burns have improved, the need for effective treatments for chronic pain in this population has become more pressing.

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Higher Reoperation Rates After Microvascular Decompression in Patients With Diabetes, Obesity

Higher Reoperation Rates After Microvascular Decompression in Patients With Diabetes, Obesity

Microvascular decompression for trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia was found to be a largely safe procedure.

Transforaminal Epidural Steroid Injections Effective for Pain Relief in Lumbar Foraminal Spinal Stenosis

Transforaminal Epidural Steroid Injections Effective for Pain Relief in Lumbar Foraminal Spinal Stenosis

Transforaminal epidural steroid injections may be more effective in relieving pain in patients with mild to moderate vs severe lower extremity radicular pain associated with lumbar foraminal spinal stenosis.

Neuropathic Pain Common in End-Stage Knee, Hip Osteoarthritis

Neuropathic Pain Common in End-Stage Knee, Hip Osteoarthritis

Patients with end-stage knee or hip osteoarthritis were found to often experience possible neuropathic pain - particularly pain at rest vs on activity, and in men.

Updated Criteria for CRPS Diagnosis May Reveal Presence of Neuropathic Pain After TKA

Updated Criteria for CRPS Diagnosis May Reveal Presence of Neuropathic Pain After TKA

Use of the 2006 vs 2007 criteria for the diagnosis of complex regional pain syndrome may lead to the misdiagnosis of patients experiencing unexplained excessive pain after total knee arthroplasty.

New Guidelines for Opioid Use in Refractory Restless Leg Syndrome

New Guidelines for Opioid Use in Refractory Restless Leg Syndrome

Opioids may be "life-transforming" for patients with refractory restless legs syndrome when taken in relatively low total daily doses, according to new guidelines.

Limited Evidence for the Effectiveness of Oxcarbazepine in Neuropathic Pain

Limited Evidence for the Effectiveness of Oxcarbazepine in Neuropathic Pain

Evidence for the effectiveness of oxcarbazepine in painful diabetic neuropathy and other forms of neuropathic pain is limited.

Migraine and Multiple Sclerosis: What Is the Link?

Migraine and Multiple Sclerosis: What Is the Link?

Increasing evidence suggests a relationship between migraine and multiple sclerosis that is beyond comorbidity and may help clarify the pathophysiology of both disorders.

Online Cognitive Behavioral Therapy May Provide Pain Relief in Chemotherapy-Induced Peripheral Neuropathy

Online Cognitive Behavioral Therapy May Provide Pain Relief in Chemotherapy-Induced Peripheral Neuropathy

Self-guided online cognitive behavioral pain management may result in improved "worst" pain but not "average" pain compared with usual care for the treatment of painful chemotherapy-induced peripheral neuropathy.

Neuromodulation for Refractory Trigeminal Neuralgia: Expert Feedback

Neuromodulation for Refractory Trigeminal Neuralgia: Expert Feedback

Neuromodulation techniques have been explored as alternative treatment options in patients with trigeminal neuralgia who do not achieve adequate pain relief with pharmacologic therapies and surgical interventions.

Capsaicin Patch Superior to Pregabalin for Alleviating, Resolving Dynamic Mechanical Allodynia

Capsaicin Patch Superior to Pregabalin for Alleviating, Resolving Dynamic Mechanical Allodynia

Treatment with the capsaicin 8% patch Qutenza may be more effective than pregabalin for reducing the intensity and area of dynamic mechanical allodynia and for complete resolution of the disorder.

Chronic Pain in Pachyonychia Congenita May Have Neuropathic Origin

Chronic Pain in Pachyonychia Congenita May Have Neuropathic Origin

Chronic pain experienced by patients with pachyonychia congenita may be caused by damage to the peripheral nerve fibers, with the hyperalgesia and allodynia observed in affected regions likely to be manifestations of peripheral sensitization.

Chemonucleolysis With Radiopaque Gelified Ethanol May Be Effective Analgesic for Chronic Radicular Pain

Chemonucleolysis With Radiopaque Gelified Ethanol May Be Effective Analgesic for Chronic Radicular Pain

The use of percutaneous chemonucleolysis with radiopaque gelified ethanol may be safe and effective for patients with treatment-resistant chronic radicular leg pain.

Peripheral Nerve Stimulation May Provide Long-Term Pain Relief for Leprosy-Related Mononeuropathy

Peripheral Nerve Stimulation May Provide Long-Term Pain Relief for Leprosy-Related Mononeuropathy

Peripheral nerve stimulation may provide long-term pain relief in patients with painful mononeuropathy secondary to leprosy.

Spinal Cord Stimulation Reduces Pain Associated With Diabetic Polyneuropathy

Spinal Cord Stimulation Reduces Pain Associated With Diabetic Polyneuropathy

After 5 years, 55% of patients had experienced treatment success and 80% of patients with a permanent implant still used their SCS device.

Acupuncture May Alleviate Pain in Idiopathic Trigeminal Neuralgia

Acupuncture May Alleviate Pain in Idiopathic Trigeminal Neuralgia

Acupuncture may reduce pain intensity and mechanical thresholds in patients with idiopathic trigeminal neuralgia.

Pain in Elite Athletes: IOC Recommendations on Contributing Factors and Treatment Approach

Pain in Elite Athletes: IOC Recommendations on Contributing Factors and Treatment Approach

Pain management in athletes requires a clear understanding of the different types of pain and various factors that can contribute to pain in this population.

Virtual Reality Effective on Spinal Cord Injury-Related Chronic Neuropathic Pain

Virtual Reality Effective on Spinal Cord Injury-Related Chronic Neuropathic Pain

The use of virtual reality (VR) and multisensory stimulation in patients with spinal cord injury promotes mild relief from chronic neuropathic pain and represents a potentially helpful addition to SCI neurorehabilitation management.

Hypoalgesia, Hyperalgesia Linked to Multiple Sclerosis Lesion Location

Hypoalgesia, Hyperalgesia Linked to Multiple Sclerosis Lesion Location

In patients with multiple sclerosis, lesions in the right dorsolateral prefrontal cortex and posterior periventricular area may be associated with hypo and hyperalgesia.

Dronabinol Safe and Effective for Neuropathic Pain Associated With Multiple Sclerosis

Dronabinol Safe and Effective for Neuropathic Pain Associated With Multiple Sclerosis

Dronabinol provides a safe and effective treatment option for patients with symptoms of neuropathic pain associated with multiple sclerosis.

Peripheral Neuropathy in Patients With HIV: Association With Additional Pain Disorders

Peripheral Neuropathy in Patients With HIV: Association With Additional Pain Disorders

Patients with a diagnosis of HIV and peripheral neuropathy often have ≥1 additional pain disorders.

Peripheral Nerve Surgery for Burn Survivors: Improving Outcomes Through Clinician Self-Analysis

Peripheral Nerve Surgery for Burn Survivors: Improving Outcomes Through Clinician Self-Analysis

As survival rates for patients with burns have improved, the need for effective treatments for chronic pain in this population has become more pressing.

Chemotherapy-Induced Peripheral Neuropathy: Mechanism Identified

Chemotherapy-Induced Peripheral Neuropathy: Mechanism Identified

The researchers found that paclitaxel triggers CIPN by altering IP3 receptor phosphorylation and intracellular calcium flux and activating calcium-dependent calpain proteases.

Cryotherapy May Prevent Symptoms of Chemotherapy-Induced Peripheral Neuropathy

Cryotherapy May Prevent Symptoms of Chemotherapy-Induced Peripheral Neuropathy

A recent study evaluated the efficacy of cryotherapy for chemo-induced peripheral neuropathy; study participants wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion.

Trigeminal Neuralgia Linked to Multiple Sclerosis: Comparing Surgical Interventions

Trigeminal Neuralgia Linked to Multiple Sclerosis: Comparing Surgical Interventions

Radiofrequency rhizotomy and the more expensive stereotactic radio surgery provide immediate pain relief from trigeminal neuralgia associated with multiple sclerosis.

Acupuncture for Chronic Pain Relief in Military Populations

Acupuncture for Chronic Pain Relief in Military Populations

Electrical stimulation and a higher baseline pain score were shown to be associated with a higher chance of improved pain relief with acupuncture.

Neuropathy Associated With Adjuvant Chemotherapy: Characteristics

Neuropathy Associated With Adjuvant Chemotherapy: Characteristics

Chronic pain following adjuvant chemotherapy with docetaxel or oxaliplatin may be solely account for by pure sensory neuropathy.

Neuroinflammation in Neuropathic Pain Indicated by Elevated Levels of Proinflammatory Chemokines in CSF

Neuroinflammation in Neuropathic Pain Indicated by Elevated Levels of Proinflammatory Chemokines in CSF

Patients with neuropathic pain have elevated levels of a set of pro-inflammatory chemokines compared with healthy individuals, suggesting ongoing neuroinflammation.

FDA Approves New Treatment for Diabetic Peripheral Neuropathy, Postherpetic Neuralgia

FDA Approves New Treatment for Diabetic Peripheral Neuropathy, Postherpetic Neuralgia

The FDA has approved Lyrica CR, a once-daily treatment for the management of neuropathic pain associated with diabetic peripheral neuropathy and the management of postherpetic neuralgia.

Opioid, Gabapentin Combo Rx May Increase Mortality Risk

Opioid, Gabapentin Combo Rx May Increase Mortality Risk

Both gabapentin and opioids are commonly prescribed for the treatment of pain, making the likelihood of these two agents being prescribed together high.

Chronic Inflammatory Demyelinating Polyneuropathy: Privigen Gains FDA Approval

Chronic Inflammatory Demyelinating Polyneuropathy: Privigen Gains FDA Approval

Privigen is stabilized with proline, which has been shown to reduce IgG aggregation and dimer formation.

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