Neuropathic Pain

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Cannabinoids May Provide Limited Relief From Neuropathic Pain

Cannabinoids May Provide Limited Relief From Neuropathic Pain

Selective cannabinoids may provide limited relief from chronic neuropathic pain and improvements in quality of life and sleep.

Association Between Osteoporosis and Multiple Sclerosis

Association Between Osteoporosis and Multiple Sclerosis

Patients with multiple sclerosis (MS) have lower bone mineral density and greater rates of osteoporosis than healthy controls.

Long-Term Opioids Associated With Worse Functional Status, Adverse Events in Polyneuropathy

Long-Term Opioids Associated With Worse Functional Status, Adverse Events in Polyneuropathy

Polyneuropathy may increase the likelihood of patients receiving long-term opioid therapy.

Genetic Variant Tied to Systemic Lupus Identified

Genetic Variant Tied to Systemic Lupus Identified

A genetic variant that is associated with both multiple sclerosis and systemic lupus erythematosus has been identified.

Trigeminal Neuralgia: Assessing Treatment Patterns to Improve Outcomes

Trigeminal Neuralgia: Assessing Treatment Patterns to Improve Outcomes

In a 3-year period, 45% of patients with trigeminal neuralgia received at least 3 unique treatments.

Cibinetide for the Treatment of Sarcoidosis

Cibinetide for the Treatment of Sarcoidosis

Cibinetide, an innate repair receptor agonist, was shown to exert disease-modifying effects by reversing sarcoidosis-related nerve loss in the cornea and skin.

Bortezomib-Induced Neuropathy From First to Second Treatment for Multiple Myeloma

Bortezomib-Induced Neuropathy From First to Second Treatment for Multiple Myeloma

Bortezomib-induced peripheral neuropathy does not worsen between initial treatment and retreatment in patients with multiple myeloma.

Capsaicin 8% Patch Effective on Nondiabetic Peripheral Neuropathic Pain

Capsaicin 8% Patch Effective on Nondiabetic Peripheral Neuropathic Pain

Results from the ASCEND study recently published in BioMed Central Neurology indicate that an 8% capsaicin patch is effective in relieving peripheral neuropathic pain resulting from a wide range of etiologies.

Antidepressant Serum Levels may be Lower in Cigarette Smokers

Antidepressant Serum Levels may be Lower in Cigarette Smokers

Serum concentration levels of several antidepressants were lower in cigarette smokers vs non-smokers.

Preclinical Pain as a Marker for Amyotrophic Lateral Sclerosis

Preclinical Pain as a Marker for Amyotrophic Lateral Sclerosis

Pain is far more common and widespread in ALS than previously suspected, and initial pain symptoms may predate the clinical onset of the disease's hallmark motor dysfunction by as much as 2 years.

Ketamine for Refractory Neuropathic Pain

Ketamine for Refractory Neuropathic Pain

A ketamine regimen is superior to methadone, or ketamine combined with methadone, in alleviating neuropathic pain and associated sensory changes.

Is Opioid-Induced Hyperalgesia Lessened by Switching to Buprenorphine?

Is Opioid-Induced Hyperalgesia Lessened by Switching to Buprenorphine?

Changes in several measures of pain in patients suspected of opioid-induced hyperalgesia were observed after transitioning from opioids to buprenorphine.

Drugs Effective on Diabetic Peripheral Neuropathy-Related Pain

Drugs Effective on Diabetic Peripheral Neuropathy-Related Pain

Several classes of drugs reduce neuropathy-related pain better than placebo.

DRG Stimulation Superior to Spinal Cord Stimulation for Lower Extremity Pain

DRG Stimulation Superior to Spinal Cord Stimulation for Lower Extremity Pain

Dorsal root ganglion stimulation is more likely than spinal cord stimulation to provide pain relief in patients with neuropathic pain conditions affecting the lower extremities.

Pregabalin for Sciatica: Is It Effective?

Pregabalin for Sciatica: Is It Effective?

In patients with sciatica pain, treatment with pregabalin did not significantly reduce pain intensity compared with placebo.

Neuropathic Pain Complexity Requires Thoughtful Approach and Combination of Interventions

Neuropathic Pain Complexity Requires Thoughtful Approach and Combination of Interventions

The wide range of etiologies underlying neuropathic pain render it a particularly challenging condition to manage.

Central Neuropathic Pain Syndromes

Central Neuropathic Pain Syndromes

Differentiating central neuropathic pain from musculoskeletal or peripheral neuropathic pain can be challenging.

Diabetic Neuropathy: Updated Position Statement by the American Diabetes Association

Diabetic Neuropathy: Updated Position Statement by the American Diabetes Association

The American Diabetes Association released an updated position statement on the prevention, detection, and management of diabetic neuropathies.

Optic Neuritis RENEW Trial Results

Optic Neuritis RENEW Trial Results

The human monoclonal antibody opicinumab may potentially enhance spontaneous remyelination after acute optic neuritis.

Neurofeedback for Chemotherapy-induced Peripheral Neuropathy

Neurofeedback for Chemotherapy-induced Peripheral Neuropathy

Patients in the neurofeedback group reported significant declines in CIPN symptoms, compared with patients who did not get neurofeedback training.

Optimal Management of Post-mastectomy Pain Syndrome

Optimal Management of Post-mastectomy Pain Syndrome

Limited data suggest antidepressants, topical capsaicin, and fat grafting may reduce pain associated with post-mastectomy pain syndrome, but more and better studies are needed to determine optimal management for this debilitating condition.

Risks Associated With Neuropathic Pain Treatment

Risks Associated With Neuropathic Pain Treatment

Death and serious outcomes resulting from overdose or poisoning from drugs used to treat depression more than doubled during the last decade and a half, found a recent study, with amitriptyline topping the list.

Viewing Photographs Reduces Pain Ratings in Patients With Chronic Pain

Viewing Photographs Reduces Pain Ratings in Patients With Chronic Pain

Viewing photographs can decrease pain intensity in patients with chronic pain.

Proliferative Diabetic Retinopathy: Outcomes With Ranibizumab vs Panretinal Photocoagulation

Proliferative Diabetic Retinopathy: Outcomes With Ranibizumab vs Panretinal Photocoagulation

Cumulative probability of proliferative diabetic retinopathy worsening was 42% in the panretinal photocoagulation group vs 34% in the ranibizumab group.

Classification of Peripheral Neuropathic Pain Based on Sensory Profiles

Classification of Peripheral Neuropathic Pain Based on Sensory Profiles

Researchers identified 3 subgroups of patients with peripheral neuropathic pain, based on sensory signs and symptoms.

Safety, Efficacy of Nonparticulate and Particulate Corticosteroids in Epidural Injections

Safety, Efficacy of Nonparticulate and Particulate Corticosteroids in Epidural Injections

Similar efficacy, superior safety of nonparticulate vs particulate corticosteroids for alleviating radicular pain.

Assessing Pregabalin Efficacy With Concomitant Neuropathic Pain Medications

Assessing Pregabalin Efficacy With Concomitant Neuropathic Pain Medications

The therapeutic efficacy of pregabalin in treating 2 types neuropathic pain (NeP) is not influenced by concomitant NeP medications.

Risk Factor Analysis for Severe Dry Eye Symptoms

Risk Factor Analysis for Severe Dry Eye Symptoms

Pain perception and severity are important when evaluating and managing dry eye.

Targeted Steroid Injection Via Epidural Catheter vs Standard C7-T1 Approach for Radicular Pain

Targeted Steroid Injection Via Epidural Catheter vs Standard C7-T1 Approach for Radicular Pain

Transforaminal approach to the treatment of cervical radicular pain presents risks.

Toward a New Class of Analgesics for Neuropathic Pain

Toward a New Class of Analgesics for Neuropathic Pain

Recent findings offer a new avenue for the development of peripheral analgesics with minimal adverse effects.