Neuropathic Pain

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Peripheral Neuropathy Management in the Primary Care Setting: A Guide

Peripheral Neuropathy Management in the Primary Care Setting: A Guide

Although peripheral neuropathy is one of the most common neurologic problems seen in the primary care setting, recognizing and evaluating peripheral neuropathy in a patient can be challenging due to its diverse presentations.

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Central Risk Factors May Contribute to Neuropathic-Like Knee Pain

Central Risk Factors May Contribute to Neuropathic-Like Knee Pain

Neuropathic-like knee pain may be driven by central risk factors that include depression, anxiety, and pain catastrophizing.

FDA Fast-Tracks Non-Opioid Treatment for Neuropathic Pain

FDA Fast-Tracks Non-Opioid Treatment for Neuropathic Pain

The treatment is currently being evaluated in a Phase 2 study (ELEVATE) in patients with major depressive disorder who have had an inadequate response to standard antidepressant therapy.

Predicting Success of Focal Nerve Surgery Based on Diagnostic Block Response

Predicting Success of Focal Nerve Surgery Based on Diagnostic Block Response

The efficacy of a diagnostic nerve block may be a poor predictor of the success of surgery for focal nerve injury.

Altered Brain Connectivity Patterns Associated With THC-Induced Analgesia

Altered Brain Connectivity Patterns Associated With THC-Induced Analgesia

A reduction in the functional connectivity between the sensorimotor cortex and the anterior cingulate cortex and dorsolateral prefrontal cortex may be associated with δ-9-tetrahydrocannabinol-associated analgesia in patients with chronic radicular neuropathic pain.

Is Pregabalin Effective for Chronic, Post-Traumatic Neuropathic Pain?

Is Pregabalin Effective for Chronic, Post-Traumatic Neuropathic Pain?

The primary outcome measure was pain rated in a diary completed by telephone each evening; secondary outcomes included measures of overall status, pain-related activity limitation, and sleep.

ZTlido Patch for Post-Shingles Pain Launching Soon

ZTlido Patch for Post-Shingles Pain Launching Soon

The non-aqueous adhesive patch requires 36mg per topical system to achieve the same therapeutic dose as Lidoderm (lidocaine 5%) which contains 700mg per patch.

Neuropathic Pain Medications

Chart with medications used to treat neuropathic pain, including diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia.

Higher PainDETECT Scores, Neuropathic Pain Preoperatively May Increase Risk for Chronic Pain Post-TKR

Higher PainDETECT Scores, Neuropathic Pain Preoperatively May Increase Risk for Chronic Pain Post-TKR

Individuals with knee osteoarthritis who have indicators of high vs low/no levels of neuropathic pain may be at elevated risk for chronic pain after total knee replacement surgery.

Hypoesthesia for Touch and Joint Position Linked to Chronic Pain in MS

Hypoesthesia for Touch and Joint Position Linked to Chronic Pain in MS

Investigators examined whether chronic pain and hypoesthesia are linked in patients with MS.

Neuropathic Symptoms Worsen Quality of Life, Function in Hip, Knee Osteoarthritis

Neuropathic Symptoms Worsen Quality of Life, Function in Hip, Knee Osteoarthritis

Neuropathic-like symptoms may affect pain-related quality of life ratings and function in patients with hip and knee osteoarthritis, respectively.

Are Anticonvulsants Effective for Low Back Pain?

Are Anticonvulsants Effective for Low Back Pain?

For this review, the authors searched 5 large databases for studies that compared the use of anticonvulsants (i.e., topiramate, gabapentin, pregabalin) in adult patients with LBP, sciatica, or neurogenic claudication with placebo.

Ultrasound-Guided Pulsed Radiofrequency May Be Effective for Thoracic Post-Herpetic Neuralgia Pain

Ultrasound-Guided Pulsed Radiofrequency May Be Effective for Thoracic Post-Herpetic Neuralgia Pain

Ultrasound-guided pulsed radiofrequency applied to intercostal nerves may be safe and effective for managing thoracic postherpetic neuralgia-associated pain.

Sustained-Release Sodium Nitrite for Diabetic Neuropathic Pain Not Associated With Headaches

Sustained-Release Sodium Nitrite for Diabetic Neuropathic Pain Not Associated With Headaches

A sustained-release formulation of sodium nitrite may not be associated with headaches and dizziness reported by patients treated with the immediate-release formulation of sodium nitrite for diabetic peripheral neuropathy.

EEG Features as Markers of Neuropathic Pain in Spinal Cord Injury

EEG Features as Markers of Neuropathic Pain in Spinal Cord Injury

Patients with subacute spinal cord injury may present electroencephalographic features that predate the onset of neuropathic pain and may serve both as markers and predictors of neuropathic pain.

Multiple Sclerosis Pain Common Disruptive Factor in Everyday Activities

Multiple Sclerosis Pain Common Disruptive Factor in Everyday Activities

Pain in patients with multiple sclerosis may affect their daily functioning regardless of disease severity.

Pediatric Chemotherapy May Be Associated With Long-Term Peripheral Neuropathy

Pediatric Chemotherapy May Be Associated With Long-Term Peripheral Neuropathy

Childhood cancer survivors are at risk for long-term peripheral neuropathy, particularly when treated with cisplatin.

Upcoming Study to Test Efficacy of Acupuncture in Treating Diabetic Peripheral Neuropathy

Upcoming Study to Test Efficacy of Acupuncture in Treating Diabetic Peripheral Neuropathy

Investigators hypothesize that needle and laser acupuncture may improve clinical and subjective symptoms in patients with diabetic peripheral neuropathy.

Point-of-Care Conduction Device May Accurately Screen for Polyneuropathy in At-Risk Populations

Point-of-Care Conduction Device May Accurately Screen for Polyneuropathy in At-Risk Populations

A point-of-care conduction device may provide accurate measurements of nerve amplitude potential and conduction velocity for the diagnosis of polyneuropathy in older patients.

Capsaicin 8% Patch May Be Effective in Neuropathic Pain

Capsaicin 8% Patch May Be Effective in Neuropathic Pain

The use of a topical capsaicin 8%may be effective in neuropathic pain associated with postherpetic neuralgia or resulting from trauma or surgery.

Clinical and Research Applications of Screening and Assessment Questionnaires for Neuropathic Pain

Clinical and Research Applications of Screening and Assessment Questionnaires for Neuropathic Pain

Specific countries officially recommend some screening questionnaires for the early assessment of neuropathic pain, with France recommending the DN4 and Germany recommending PainDETECT.

Factors Associated With Neuropathic Pain in Ankylosing Spondylitis

Factors Associated With Neuropathic Pain in Ankylosing Spondylitis

A number of factors that include age, the presence of enthesitis, and depressive symptoms may be associated with neuropathic pain in ankylosing spondylitis.

Catastrophizing and Function in Chronic Spinal Pain

Catastrophizing and Function in Chronic Spinal Pain

Pain catastrophizing may be associated with reduced psychological — and to a lesser extent physical —function in patients with neuropathic pain and spinal pain.

Balloon Angioplasty Provides Clinical Relief in Headache-Positive MS

Balloon Angioplasty Provides Clinical Relief in Headache-Positive MS

Percutaneous transluminal angioplasty maybe beneficial for reducing headaches in relapsing remitting and secondary progressive multiple sclerosis.

Bipolar Radiofrequency Thermocoagulation for Trigeminal Neuralgia

Bipolar Radiofrequency Thermocoagulation for Trigeminal Neuralgia

Patients with V3 trigeminal neuralgia may get greater benefit from bipolar vs unipolar radiofrequency thermocoagulation.

Severe MS Associated With Increased Neuropathic Pain Risk

Severe MS Associated With Increased Neuropathic Pain Risk

Neuropathic pain is associated with a more severe multiple sclerosis disease phenotype.

Reviewing the Efficacy, Safety, and Tolerability of Cannabis-Based Medicines for Chronic Neuropathic Pain

Reviewing the Efficacy, Safety, and Tolerability of Cannabis-Based Medicines for Chronic Neuropathic Pain

The effectiveness of cannabis-based products for chronic neuropathic pain is not supported by high-quality evidence.

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in Type 1 vs Type 2 Diabetes

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in Type 1 vs Type 2 Diabetes

The type of sciatic nerve lesions observed in patients with diabetic peripheral neuropathy was found to differ in type 1 and type 2 diabetes.

ZTlido Approved to Treat Pain Associated With Postherpetic Neuralgia

ZTlido Approved to Treat Pain Associated With Postherpetic Neuralgia

ZTlido is comprised of a non-aqueous adhesive material containing 1.8% lidocaine.

Peripherally Acting Opioid and Cannabinoid May Be Effective for Neuropathic Pain

Peripherally Acting Opioid and Cannabinoid May Be Effective for Neuropathic Pain

Cotargeting of peripheral μ-opioid and cannabinoid receptors was found to have a synergistic effect in reducing mechanical allodynia in a mouse model of neuropathic pain.

Positive Affect, Resilience, and Pain in MS With Chronic Pain

Positive Affect, Resilience, and Pain in MS With Chronic Pain

Resilience may mediate the relationships between positive affect and pain interference and depression in patients with multiple sclerosis.