Generic Name and Formulations:
Primidone 50mg, 250mg; scored tabs.
Bausch Health Companies Inc.
Indications for MYSOLINE:
Tonic-clonic, focal and psychomotor seizures.
Initially: 100–125mg at bedtime. Increase every 3 days if needed by 100–125mg daily to 3 times daily on day 7. On day 10, increase to 250mg 3 times daily; max 2g daily in divided doses.
<8yrs: initially 50mg at bedtime. On day 4, increase if needed to 50mg twice daily. On day 7, to 100mg twice daily. On day 10, to 125–250mg 3 times daily. Usual maintenance: 100–250mg 3 times daily or 10–25mg/kg/day in divided doses. ≥8yrs: as adult.
Porphyria. Barbiturate hypersensitivity.
Impaired liver function. Change dose gradually. Monitor blood counts, electrolytes. Pregnancy. Nursing mothers.
Potentiated with alcohol and other CNS depressants. Antagonizes oral anticoagulants and contraceptives, steroids, Vit. K and D, griseofulvin, doxycycline. Variable effects with phenytoin, valproic acid, divalproex. Potentiated by MAOIs. Antagonizes tricyclic antidepressants.
Drowsiness, ataxia, dizziness, nystagmus, neonatal hemorrhage and withdrawal, nausea, vomiting, rash, megaloblastic anemia sensitive to folic acid, emotional disorders, impotence.
Tabs 50mg—100, 500; 250mg—100, 1000
Clinical Pain Advisor Articles
- Analyzing Coverage of Nonpharmacologic Treatments for Low Back Pain
- Smartphone App Helps Evaluate Catastrophizing in Chronic Pain
- Predicting the Magnitude of Placebo Analgesia in Chronic Pain
- Dsuvia Gains FDA Approval: We Want to Hear Your Thoughts
- Operant Learning May Provide More Benefits Than Energy Conservation in Fibromyalgia
- The Unintended Consequences of the CDC Opioid Guideline According to Pain Management Specialists
- Seven-Item Pain Intensity Measure Reliable in Individuals With Dementia
- Initial Consultation for Neck Pain May Reduce Opioid Consumption, Healthcare Utilization
- FDA-Approved Test Provides Pharmacogenetic Reports Directly to Consumers
- Set of Interventions May Effectively Reduce Opioid Overprescribing
- Methamphetamine Use on the Rise in Patients With Opioid Use Disorder
- Two Screening Tools May Accurately Predict Transition From Acute to Chronic Low Back Pain
- Dozens of Medical Groups Join Forces to Improve Diagnoses
- FDA Grants Non-Opioid Analgesic VVZ-149 Fast Track Status
- Little to No Association Found Between Physician Performance and Medical School Ranking