Gout Medications

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GOUT TREATMENTS

Non-pharmacologic therapy includes lifestyle and
dietary changes such as weight management,
reduced alcohol intake and consumption of high
purine foods (ex. anchovies, asparagus, game meats,
gravy, herring, liver, mackerel, mushrooms, sardines,
scallops), as well as maintenance of blood
pressure and lipid control.

Generic Brand Form Strength Notes
Acute Attack
colchicine Colcrys tabs 0.6mg  
colchicinum 4X-
Colcigel gel 0.25mL/pump actuation

• Avoid eyes

• Discontinue if irritation, sensitivity, infection, or toxicity is suspected or occurs

indomethacin caps 25mg, 50mg

• Use lowest effective dose and shortest duration

• Discontinue if experiencing
severe side effects

supp 50mg
Indocin Susp susp 25mg/5mL
methylpred-
nisolone
Depo-Medrol susp for inj 20mg/mL, 40mg/mL, 80mg/mL

• Gently move joint after IA inj to aid mixing of susp with synovial fluid

naproxen Naprosyn tabs 250mg+, 375mg, 500mg+

• EC-Naprosyn not recommended

• Use lowest effective dose and duration

susp 125mg/
 
5mL
Anaprox tabs 275mg  
Anaprox DS tabs 550mg  
Naprelan controlled release tabs 375mg, 500mg, 750mg  
prednisone scored tabs 1mg, 2.5mg, 5mg, 10mg, 20mg, 50mg  
soln 5mg/5mL
intensol 5mg/mL
Rayos del-rel tabs 1mg, 2mg, 5mg

• Use lowest effective dose

• Withdraw gradually

• Take with food

sulindac Clinoril scored tabs 200mg

• Use lowest effective dose and shortest duration

• Take with food

• Max dose: 400mg/day

triamcinolone hexacetonide Aristospan
Intra-articular
susp for inj 20mg/mL  
Chronic/Management/Prevention
allopurinol Zyloprim scored tabs 100mg, 300mg

• Take with food

• Ensure adequate fluid intake to yield ≥2L daily urine output

• Maintain alkaline or neutral urine

• Administer in divided doses

• Max dose: 800mg/day and 300mg/dose

• Discontinue if rash appears

colchicine Colcrys tabs 0.6mg  
Mitigare caps 0.6mg
colchicinum 4X-
Colcigel gel 0.25mL/pump actuation

• Avoid eyes

• Discontinue if irritation, sensitivity, infection, or toxicity is suspected or occurs

febuxostat Uloric tabs 40mg, 80mg

• Gout flare prophylaxis, with an NSAID or colchicine, upon initiation of therapy and for up to 6mos, is recommended.

pegloticase Krystexxa soln for IV infusion after 
dilution
8mg/mL

• Discontinue oral urate-lowering agents before starting; do not institute while on pegloticase therapy

• Give by IV infusion over at least 2hrs and premedicate with antihistamines and corticosteroids

• Slow rate, or stop and restart at lower rate, if infusion reaction occurs; observe at least 1hr post-infusion

probenecid scored tabs 500mg

• Take with plenty of fluids

• Maintain alkaline or neutral urine

• Reduce dose if GI intolerance occurs

probenecid/
colchicine
scored tabs 500mg/
 
0.5mg

• Take with plenty of fluids

• Maintain alkaline or neutral urine

• Reduce dose if GI intolerance occurs

NOTES

Key: + = scored tabs; IA = intra-articular; soln = solution; susp = suspension; supp = suppositories

REFERENCES

Adapted from: National Institute of Arthritis and Musculoskeletal and Skin Diseases. 2002 [updated 2012]. National Institutes of Health (www.niams.nih.gov)

(Rev. 11/2015)

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