Morphine

Morphine and Oxycodone Abuse-Deterrent Formulations Lower Absorption Rates

Morphine and Oxycodone Abuse-Deterrent Formulations Lower Absorption Rates

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Administration of abuse-deterrent formulations of immediate-release oxycodone and extended-release morphine leads to slower and lower absorption rates in nondependent recreational drug users compared with standard oxycodone and morphine formulations.

Morphine Lacks Efficacy for RA, Chronic Fatigue Syndrome and Fibromyalgia

Morphine Lacks Efficacy for RA, Chronic Fatigue Syndrome and Fibromyalgia

For patients with chronic fatigue syndrome/fibromyalgia or rheumatoid arthritis, morphine has anti-hyperalgesic effects comparable with placebo.

Intrathecal Ziconotide Long-Term Efficacy and Safety for Severe Chronic Pain

Intrathecal Ziconotide Long-Term Efficacy and Safety for Severe Chronic Pain

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In patients with severe chronic pain refractory to conventional therapy, intrathecal ziconotide provided long-term pain relief, particularly when used as first-line intrathecal therapy.

Neonatal Abstinence Syndrome Effectively Treated With Buprenorphine

Neonatal Abstinence Syndrome Effectively Treated With Buprenorphine

In infants with neonatal abstinence syndrome, sublingual buprenorphine reduced the duration of treatment and decreased the length of hospital stay.

Morphine Microdose Therapy Safe, Effective in Chronic Non-Cancer Pain

Morphine Microdose Therapy Safe, Effective in Chronic Non-Cancer Pain

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The low dose of the microdose method reduces the formation of catheter tip granuloma.

Perioperative Lidocaine Offers No Benefits in Patients Undergoing Spinal Fusion

Perioperative Lidocaine Offers No Benefits in Patients Undergoing Spinal Fusion

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Perioperative lidocaine does not reduce morphine use in the first 24 hours after posterior arthrodesis and offers no measurable benefits.

Certain Chronic Pain Medications May Have Endocrinologic Side Effects

Certain Chronic Pain Medications May Have Endocrinologic Side Effects

Chronic pain patients being treated with certain opioid and non-opioid medications had significantly lower serum concentrations of free testosterone and free estradiol.

Sublingual Fentanyl Preferred, But Less Effective Than Subcutaneous Morphine

Sublingual Fentanyl Preferred, But Less Effective Than Subcutaneous Morphine

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Fentanyl sublingual tablets are preferred over subcutaneous morphine in patients with severe breakthrough cancer pain.

Identifying Patients With Higher Methadone Dose Requirements

Identifying Patients With Higher Methadone Dose Requirements

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Polymorphism at the level of drug receptors, transporters, or other proteins involved in drug metabolism or action may have an impact on the effect of a drug.

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