Morphine

Methadone Improves Short-Term Outcomes Better Than Morphine in Neonatal Abstinence Syndrome

Methadone Improves Short-Term Outcomes Better Than Morphine in Neonatal Abstinence Syndrome

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Methadone may be superior to morphine for reducing hospital length of stay and length of drug treatment in infants with neonatal abstinence syndrome.

Storage and Disposal Information on Opioid Package Inserts Insufficient

Storage and Disposal Information on Opioid Package Inserts Insufficient

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Oxycodone and morphine are more likely to contain messaging on package inserts describing safe storage and disposal methods compared with other commonly used and misused opioid analgesics.

Opioids Often Over-Prescribed After Hiatal Hernia Surgery

Opioids Often Over-Prescribed After Hiatal Hernia Surgery

The researchers found that the median prescription size was 350 mg oral morphine equivalents and median patient use was 225 mg oral morphine equivalents following open hiatal hernia repair.

Hydrocodone, Oxycodone Linked to Majority of Serious Opioid Adverse Event Cases

Hydrocodone, Oxycodone Linked to Majority of Serious Opioid Adverse Event Cases

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The 7 opioids included for analysis were oxycodone, hydrocodone, morphine, hydromorphone, oxymorphone, tapentadol, and tramadol.

An Avenue for the Development of Opioid Adjuncts for Enhanced Analgesia, Reduced Abuse Potential

An Avenue for the Development of Opioid Adjuncts for Enhanced Analgesia, Reduced Abuse Potential

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Suppression of the function of an intracellular modulator of the μ-opioid receptor was found to enhance the analgesic activity of agonists for those receptors, delay the tolerance to morphine and reduce its rewarding effects

Slow-Release Oral Morphine, a Promising Opioid Agonist Therapy Alternative to Buprenorphine, Methadone

Slow-Release Oral Morphine, a Promising Opioid Agonist Therapy Alternative to Buprenorphine, Methadone

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Slow-release oral morphine may be a valuable tool to help reduce the number of deaths from opioid-related overdose.

Low-Dose Ketamine Provides Comparable Acute Pain Relief, More Adverse Events Than Morphine

Low-Dose Ketamine Provides Comparable Acute Pain Relief, More Adverse Events Than Morphine

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Acute pain management in the emergency department with low-dose ketamine may provide pain relief comparable with morphine at 30 minutes.

Midazolam Plus Morphine: Continuous vs Intermittent Infusions for Pediatric Postsurgical Pain

Midazolam Plus Morphine: Continuous vs Intermittent Infusions for Pediatric Postsurgical Pain

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Continuous infusions of midazolam plus morphine do not provide additional pain relief compared with intermittent dosing of those drugs, and may increase hospital length of stay among pediatric patients who have undergone cardiac surgery.

Ibuprofen Comparable With Morphine for Postoperative Pain in Children

Ibuprofen Comparable With Morphine for Postoperative Pain in Children

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Among children who have undergone minor outpatient orthopedic surgery, ibuprofen provides equivalent postoperative pain relief compared with oral morphine.

Morphine and Oxycodone Abuse-Deterrent Formulations Lower Absorption Rates

Morphine and Oxycodone Abuse-Deterrent Formulations Lower Absorption Rates

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Administration of abuse-deterrent formulations of immediate-release oxycodone and extended-release morphine leads to slower and lower absorption rates in nondependent recreational drug users compared with standard oxycodone and morphine formulations.

Morphine Lacks Efficacy for RA, Chronic Fatigue Syndrome and Fibromyalgia

Morphine Lacks Efficacy for RA, Chronic Fatigue Syndrome and Fibromyalgia

For patients with chronic fatigue syndrome/fibromyalgia or rheumatoid arthritis, morphine has anti-hyperalgesic effects comparable with placebo.

Intrathecal Ziconotide Long-Term Efficacy and Safety for Severe Chronic Pain

Intrathecal Ziconotide Long-Term Efficacy and Safety for Severe Chronic Pain

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In patients with severe chronic pain refractory to conventional therapy, intrathecal ziconotide provided long-term pain relief, particularly when used as first-line intrathecal therapy.

Neonatal Abstinence Syndrome Effectively Treated With Buprenorphine

Neonatal Abstinence Syndrome Effectively Treated With Buprenorphine

In infants with neonatal abstinence syndrome, sublingual buprenorphine reduced the duration of treatment and decreased the length of hospital stay.

Morphine Microdose Therapy Safe, Effective in Chronic Non-Cancer Pain

Morphine Microdose Therapy Safe, Effective in Chronic Non-Cancer Pain

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The low dose of the microdose method reduces the formation of catheter tip granuloma.

Perioperative Lidocaine Offers No Benefits in Patients Undergoing Spinal Fusion

Perioperative Lidocaine Offers No Benefits in Patients Undergoing Spinal Fusion

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Perioperative lidocaine does not reduce morphine use in the first 24 hours after posterior arthrodesis and offers no measurable benefits.

Certain Chronic Pain Medications May Have Endocrinologic Side Effects

Certain Chronic Pain Medications May Have Endocrinologic Side Effects

Chronic pain patients being treated with certain opioid and non-opioid medications had significantly lower serum concentrations of free testosterone and free estradiol.

Sublingual Fentanyl Preferred, But Less Effective Than Subcutaneous Morphine

Sublingual Fentanyl Preferred, But Less Effective Than Subcutaneous Morphine

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Fentanyl sublingual tablets are preferred over subcutaneous morphine in patients with severe breakthrough cancer pain.

Identifying Patients With Higher Methadone Dose Requirements

Identifying Patients With Higher Methadone Dose Requirements

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Polymorphism at the level of drug receptors, transporters, or other proteins involved in drug metabolism or action may have an impact on the effect of a drug.

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