Migraine

Erenumab Shows Promise in Treatment-Resistant Migraine

Erenumab Shows Promise in Treatment-Resistant Migraine

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A recent study evaluated the safety and efficacy of erenumab in patients with episodic migraine who had experienced 2 to 4 previous preventive treatment failures, due to lack of efficacy or intolerable side effects.

Evaluating Day-to-Day Variations in Migraine, Non-Migraine Headaches

Evaluating Day-to-Day Variations in Migraine, Non-Migraine Headaches

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The frequency, intensity, and daily interference of headaches change over a 6-month period, with day-to-day variation being more volatile in migraine than in non-migraine headaches.

CGRP Antagonist Shows Effectiveness in Acute Migraine

CGRP Antagonist Shows Effectiveness in Acute Migraine

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Allergan has announced positive Phase 3 trial results for ubrogepant, a novel calcitonin gene-related peptide receptor antagonist for the acute treatment of migraine.

Episodic Migraine-Related White Matter Hyperintensities Ipsilateral to Pain

Episodic Migraine-Related White Matter Hyperintensities Ipsilateral to Pain

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Pain experienced by patients during episodic migraine is associated with the occurrence of white matter hyperintensities in the cerebral hemisphere ipsilateral to the pain side.

Chronic Migraine Linked to Insulin Resistance in Women

Chronic Migraine Linked to Insulin Resistance in Women

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A recent study assessed the relationship of fasting neuropeptide Y with insulin resistance, β-cell function, and glucagon-like peptide-1 secretion in patients with migraine.

Managing Headache During Pregnancy: Expert Insight

Managing Headache During Pregnancy: Expert Insight

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Headache screening should be a routine part of a prenatal visit so that if and when a patient presents with an attack, a suitable plan of action is already established.

Migraine, Tension-Type Headaches Likely in Adolescents Exposed to Violence

Migraine, Tension-Type Headaches Likely in Adolescents Exposed to Violence

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Adolescents exposed to violence or terror attacks have an increased risk for daily and weekly migraine and tension-type headache following the event.

Erenumab for Episodic Migraine Prophylaxis: Current Evidence

Erenumab for Episodic Migraine Prophylaxis: Current Evidence

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The monoclonal antibody erenumab has shown favorable results regarding efficacy and safety for the prevention of migraine.

OnabotulinumtoxinA for Tension-Type Headache: Research vs Real-Life Settings

OnabotulinumtoxinA for Tension-Type Headache: Research vs Real-Life Settings

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Despite its prevalence, tension-type headache is often complicated by overlapping symptoms and a weak understanding of tension-type headache etiology.

Impact of Physical Activity on Migraine in Overweight, Obese Women

Impact of Physical Activity on Migraine in Overweight, Obese Women

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A large variability in the impact of physical activity on pain during acute migraine attacks was found in women who were overweight and obese.

Type 1, Type 2 Diabetes Associated With Lower Risk for Migraine

Type 1, Type 2 Diabetes Associated With Lower Risk for Migraine

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Results from a study investigating diabetes and migraine in the Norwegian population show that type 1 and type 2 diabetes were significantly associated with a decreased risk for migraine.

FDA Approves GammaCore Treatment for Migraine Pain

FDA Approves GammaCore Treatment for Migraine Pain

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The FDA has granted GammaCore expanded clearance by the FDA to treat pain associated with migraine.

Eptinezumab Effectively Reduces Migraine Frequency in Phase 3 Trial

Eptinezumab Effectively Reduces Migraine Frequency in Phase 3 Trial

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Eptinezumab, an investigational treatment for migraine prevention, has met its pivotal Phase 3 trial primary endpoint of significant reduction in monthly migraine days vs placebo.

Migraine and Multiple Sclerosis: What Is the Link?

Migraine and Multiple Sclerosis: What Is the Link?

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Increasing evidence suggests a relationship between migraine and multiple sclerosis that is beyond comorbidity and may help clarify the pathophysiology of both disorders.

Posttraumatic Stress Disorder May Predict Headache-Related Disability After Traumatic Physical Injury

Posttraumatic Stress Disorder May Predict Headache-Related Disability After Traumatic Physical Injury

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Investigators assessed single-incident traumatic physical injury survivors for symptoms of post-traumatic stress disorder and a composite of depression and anxiety symptoms.

Risk for Suicide in Patients With Migraine and Psychiatric Comorbidities

Risk for Suicide in Patients With Migraine and Psychiatric Comorbidities

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Although patients with migraine appear to be at a higher risk for suicide than the general population, migraineurs diagnosed with depression, anxiety, or posttraumatic stress disorder do not show a suicide association.

Patent Foramen Ovale Closure May Not Reduce Migraine Headache Frequency

Patent Foramen Ovale Closure May Not Reduce Migraine Headache Frequency

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Percutaneous closure of patent foramen ovale is not associated with a reduction in migraine headaches in patients with and without aura

Neurostimulation Effective in Refractory Cervicogenic Headaches

Neurostimulation Effective in Refractory Cervicogenic Headaches

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Occipital nerve stimulation is a potentially safe and effective management strategy for daily moderate to severe refractory cervicogenic headaches.

Using the Pain Self-Efficacy Questionnaire to Assess Pain Coping After Migraine Surgery

Using the Pain Self-Efficacy Questionnaire to Assess Pain Coping After Migraine Surgery

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Administration of the Pain Self-Efficacy Questionnaire before and after migraine surgery may provide contextual information regarding migraine pain relative to other conditions.

Lomerizine Treatment May Increase Interictal Regional Cerebral Blood Flow

Lomerizine Treatment May Increase Interictal Regional Cerebral Blood Flow

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Treatment with lomerizine increases interictal regional cerebral blood flow and may reduce migraine in chronic migraineurs.

Herpes Simplex Virus Treatment Successful on Severe Headache in Case Study

Herpes Simplex Virus Treatment Successful on Severe Headache in Case Study

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Successful treatment of migraine headache with therapy specifically targeting herpes simplex virus infection is highlighted in a new case report.

Weight Loss as Effective as Migraine Education for Reducing Migraine Frequency

Weight Loss as Effective as Migraine Education for Reducing Migraine Frequency

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A behavioral weight loss strategy confers benefits similar to those of migraine education in reducing the frequency of migraine headaches.

Migraines Possibly Prevented With Prophylactic Magnesium

Migraines Possibly Prevented With Prophylactic Magnesium

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The included trials looked at magnesium administration among those with menstrual migraine, migraine with and without aura, and standard migraine symptoms.

Episodic Migraines Possibly Prevented With Subcutaneous Galcanezumab

Episodic Migraines Possibly Prevented With Subcutaneous Galcanezumab

Researchers have found that monthly subcutaneous injection of galcanezumab significantly reduce migraine headache days.

FDA Reviews Biologics License Application for Novel Migraine Prevention Treatment

FDA Reviews Biologics License Application for Novel Migraine Prevention Treatment

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The Food and Drug Administration has accepted a Biologics License Application for the investigational migraine prevention treatment, galcanezumab.

New Migraine Treatment Devices Available to Stop and Prevent Attacks

New Migraine Treatment Devices Available to Stop and Prevent Attacks

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The FDA has approved 2 new migraine treatment devices to stop and prevent migraine attacks in adults.

Prochlorperazine More Effective Than Ketamine for Treating Headaches in the Emergency Department

Prochlorperazine More Effective Than Ketamine for Treating Headaches in the Emergency Department

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Investigators found that patients receiving prochlorperazine had a greater reduction in headache-related pain compared with patients receiving ketamine.

Migraine Frequency Reduced With Erenumab, Fremanezumab

Migraine Frequency Reduced With Erenumab, Fremanezumab

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Complete results from 2 phase 3 trials examining the effects of 2 humanized monoclonal antibodies in patients with episodic and chronic migraine were published simultaneously.

Patients With Migraine Frequently Revisit the Emergency Department for Headache

Patients With Migraine Frequently Revisit the Emergency Department for Headache

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More than 25% of patients presenting to the emergency department (ED) for migraine typically require subsequent ED revisits for headache within a 6-month period.

Contraceptive Use and the Risk for Ischemic Stroke in Women With Migraine

Contraceptive Use and the Risk for Ischemic Stroke in Women With Migraine

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Consensus statement cautions against the use of hormonal contraceptives in women with migraine, as these medications may be associated with an increased risk for ischemic stroke.

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