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MEGACE ES
Anorexia/cachexia
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Drug Name:

MEGACE ES Rx

Generic Name and Formulations:
Megestrol acetate 125mg/mL; oral susp; lemon-lime flavor.

Company:
Par Pharmaceutical, Inc.

Therapeutic Use:

Indications for MEGACE ES:

Anorexia, cachexia, or unexplained significant weight loss in patients diagnosed with AIDS.

Limitations Of use:

Should only be instituted after treatable causes of weight loss are sought and addressed. Not for prophylactic use to avoid weight loss.

Adult:

625mg/5mL per day.

Children:

Not established.

Contraindications:

Known or suspected pregnancy (Cat.X).

Warnings/Precautions:

Do not substitute with other megestrol suspensions (not interchangeable). History of thromboembolic disease. Monitor for signs/symptoms of adrenal insufficiency; consider empiric therapy if occurs. Diabetes. Renal impairment. Elderly. Avoid in women of childbearing potential. Nursing mothers: not recommended.

Interactions:

May increase insulin requirements. Decreases indinavir levels.

Pharmacological Class:

Progestin.

Adverse Reactions:

Nausea, diarrhea, impotence, rash, flatulence, hypertension, asthenia; rare: adrenal insufficiency, breakthrough bleeding.

Generic Availability:

YES

How Supplied:

Concentrated susp (125mg/mL)—5oz

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