HUMALOG MIX75/25 Rx
Generic Name and Formulations:
Insulin lispro protamine suspension 75% (rDNA origin), insulin lispro 25% (rDNA origin) 100 Units/mL; SC inj; contains zinc, m-cresol.
Lilly, Eli and Company
Indications for HUMALOG MIX75/25:
≥18yrs: SC inj only. Onset approx ≤15mins, peak 1–6hrs, duration 13–22hrs.
<18yrs: not established.
During episodes of hypoglycemia.
Instruct patients on diet, exercise, blood or urine testing, proper administration of insulin, change in species of origin, type or purity of insulin, and management of hypoglycemia. Do not reuse or share pens, needles, cartridges, or syringes between patients. Dosage increase may be required during infection, illness, stress, trauma, and pregnancy. Dosage decrease may be needed with renal or hepatic dysfunction. Pregnancy (Cat.B). Nursing mothers.
Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Potentiated by oral antidiabetic agents, pramlintide, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog, sulfonamide antibiotics. Antagonized by corticosteroids, isoniazid, niacin, danazol, diuretics, thiazides, phenothiazines, sympathomimetics, somatropin, thyroid hormones, estrogens, progestogens, atypical antipsychotics. Variable effects with β-blockers, clonidine, lithium salts, alcohol, pentamidine. When mixing insulin lispro with other insulins, draw insulin lispro into syringe first and inject mixture immediately.
Hypoglycemia, hypokalemia, local or systemic allergy, lipodystrophy, edema.
Humalog Mix75/25, Humalog vials (10mL)—1; Humalog Mix, Humalog U-100 Kwikpen (prefilled) (3mL), Humalog U-100 Junior Kwikpen (prefilled) (3mL), Humalog U-200 Kwikpen (prefilled) (3mL)—5; Humalog cartridges (3mL)—5; HumaPen LUXURA HD (inj device, uses Humalog cartridges)—1
Clinical Pain Advisor Articles
- Two Screening Tools May Accurately Predict Transition From Acute to Chronic Low Back Pain
- Tools to Address the Opioid Crisis
- Methamphetamine Use on the Rise in Patients With Opioid Use Disorder
- Operant Learning May Provide More Benefits Than Energy Conservation in Fibromyalgia
- Patterns of Non-Medical Prescription Opioid Use in Adolescents
- The Unintended Consequences of the CDC Opioid Guideline According to Pain Management Specialists
- Initial Consultation for Neck Pain May Reduce Opioid Consumption, Healthcare Utilization
- FDA-Approved Test Provides Pharmacogenetic Reports Directly to Consumers
- Set of Interventions May Effectively Reduce Opioid Overprescribing
- Cannabinoid-Associated Analgesia May Be Mediated Through Modulation of Affective Processes
- FDA Panel Votes in Favor of Abuse-Deterrent Oxycodone Reformulation
- FDA Proposes New Restrictions on Sale of Electronic Nicotine Delivery Systems
- Central Sensitization in Greater Trochanteric Pain Syndrome
- Pain Acceptance May Reduce Headache-Related Disability in Migraine
- FDA Issues Safety Alert Regarding Intrathecal Delivery of Pain Meds