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FUZEON
Viral infections
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Drug Name:

FUZEON Rx

Generic Name and Formulations:
Enfuvirtide 108mg/vial; pwd for SC inj after reconstitution; preservative-free.

Company:
Genentech, Inc.

Therapeutic Use:

Indications for FUZEON:

Treatment of HIV-1 infection, in combination with other antiretroviral agents, in treatment-experienced patients with evidence of HIV-1 replication despite ongoing antiretroviral therapy.

Adult:

Give by SC inj into upper arm, anterior thigh, or abdomen (not into moles, scar tissue, bruises, or navel). Rotate inj sites. >16yrs: 90mg twice daily.

Children:

<6yrs: limited data available. Give by SC inj into upper arm, anterior thigh, or abdomen (not into moles, scar tissue, bruises, or navel). Rotate inj sites. 6–16yrs: 2mg/kg twice daily; max 90mg twice daily.

Warnings/Precautions:

Discontinue if hypersensitivity occurs; do not rechallenge. Instruct patients on proper use of Biojector 2000 needle-free device. Monitor for pneumonia (esp. if low initial CD4 cell count, high initial viral load, IV drug use, history of lung disease, or smoker). Coagulation disorders. Renal insufficiency (CrCl <35mL/min). Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Increased risk of post-injection bleed with concomitant anticoagulants. May cause false (+) ELISA test for HIV.

Pharmacological Class:

Fusion inhibitor.

Adverse Reactions:

Local inj site reactions, diarrhea, nausea, fatigue; pneumonia, hypersensitivity reactions, immune reconstitution syndrome, autoimmune disorders.

Note:

Register pregnant patients exposed to enfuvirtide by calling (800) 258-4263.

Metabolism:

Hepatic.

Elimination:

Renal.

Generic Availability:

NO

How Supplied:

Kit—1 (60 vials w. supplies)

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