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Flutamide
Prostate and other male cancers
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Drug Name:

Flutamide Rx

Generic Name and Formulations:
Flutamide 125mg; caps.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Flutamide:

In combination with LHRH agonists (GnRH analogues) in locally confined stage B2–C and stage D2 metastatic prostate carcinoma.

Adult:

250mg every 8 hrs.

Children:

Not applicable.

Contraindications:

Severe hepatic impairment. ALT ≥2xULN: not recommended.

Warnings/Precautions:

Monitor liver function at baseline, monthly for first 4 months, then periodically, and if liver dysfunction occurs; if ALT >2xULN or jaundice occurs, discontinue and monitor closely until resolution. Monitor prostate specific antigen (PSA). Consider monitoring methemoglobin levels in patients susceptible to aniline toxicity (e.g., G6PD deficiency, smokers, hemoglobin M disease). Pregnancy (Cat.D); not for use in women.

Interactions:

Monitor warfarin.

Pharmacological Class:

Antiandrogen.

Adverse Reactions:

Diarrhea, hot flashes, loss of libido, impotence, GI disturbances, gynecomastia, rash, edema, hypertension, CNS effects, blood dyscrasias, urine discoloration, liver failure.

Note:

Formerly known under the brand name Eulexin.

How Supplied:

Contact supplier.

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