Generic Name and Formulations:
Gadoxetate disodium 181.43mg/mL (0.25mol/L); soln for IV inj.
Indications for EOVIST:
For IV use in T1-weighted magnetic resonance imaging (MRI) of the liver to detect and characterize lesions in adults with known or suspected focal liver disease.
Give as IV bolus inj at a rate of 2mL/sec; flush with saline after inj. 0.1mL/kg (0.025mmol/kg). See full labeling re: imaging guidelines.
Nephrogenic systemic fibrosis.
Chronic, severe kidney disease (GFR<30mL/min/1.73m2), acute kidney injury: increased risk of nephrogenic systemic fibrosis; avoid unless necessary, allow sufficient period of time for elimination prior to re-administration. Screen for acute kidney injury and other conditions that reduce renal function (eg, >60yrs, hypertension, diabetes). Severe renal or hepatic failure. Elevated bilirubin (>3mg/dL) or ferritin may reduce hepatic contrast effect; perform MRI no later than 60 mins following administration. History of asthma/allergic disorders. Anaphylactoid reaction possible (may be fatal); have emergency resuscitative equipment available. Avoid extravasation. Pregnancy (Cat.C). Nursing mothers.
Gadolinium-based contrast agent.
Serum iron using complexometric methods may result in falsely high or low values for up to 24hrs.
Headache, dizziness, dysgeusia, parosmia, increased blood pressure, flushing, respiratory disorders, vomiting, nausea, rash, pruritus, inj site reactions, feeling hot.
Single-dose vials (10mL, 15mL)—5
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