Generic Name and Formulations:
Cysteamine bitartrate 50mg, 150mg; caps.
Indications for CYSTAGON:
Management of nephropathic cystinosis.
New patients: start on ¼ to ⅙ of the maintenance dose; increase gradually over 4–6 weeks. Maintenance: >12yrs and >110lbs: 2g/day divided 4 times daily. Max 1.95g/m2/day. Goal of therapy to keep leukocyte cystine levels below 1nmol/½ cystine/mg protein 5–6 hours after administration. Patients taking cysteamine HCl or phosphocysteamine solutions may be transferred to equimolar doses of cysteamine bitartrate.
1.3g/m2/day in 4 divided doses. Max 1.95g/m2/day. If <6yrs old: do not give intact caps; may open and sprinkle capsule contents over food.
Withhold dose if skin rash develops, may be restarted at a lower dose then titrated slowly; if severe, do not readminister. Monitor blood counts, LFTs, vision, skin, bones. Measure leukocyte cystine levels every 3 months, more frequently when transferring from cysteamine HCl or phosphocysteamine solutions. Pregnancy (Cat.C). Nursing mothers: not recommended.
Vomiting, anorexia, fever, diarrhea, lethargy, rash; skin or bone lesions (reduce dose if appears), leukopenia, abnormal LFTs, CNS effects, GI ulceration/bleeding, pseudotumor cerebri, papilledema; rare: interstitial nephritis with early renal failure.
Clinical Pain Advisor Articles
- Radiofrequency Denervation Efficacious in Treating Thoracic Zygapophyseal Joint Pain
- Prescribed Opioids Difficulties Scale Effective for Assessing Concerns of Patients With Chronic Pain
- Predictors of Opioid Overdose in High-Risk Users
- Optimal Strategies for Opioid Weaning After Ambulatory Surgery
- Emergency Physicians Offer Recommendations for Identifying and Managing Opioid Use Disorder
- Consensus Guidelines for the Use of Intravenous Ketamine for Chronic Pain
- Pain Societies Issue Guidelines on Use of Ketamine for the Management of Acute Pain
- Labor Epidural Analgesia Linked to Reduced Likelihood of Successful Breastfeeding
- Novel Oral Treatment Safe, Effective for Migraine Headache Relief
- DFN-02 Nasal Spray Safe, Effective for Acute Treatment of Episodic Migraine
- Higher PainDETECT Scores, Neuropathic Pain Preoperatively May Increase Risk for Chronic Pain Post-TKR
- Terms Used for Addiction May Be Associated With Explicit, Implicit Bias
- Erenumab Reduces Monthly Migraine Days in Patients With Treatment-Resistant Migraine
- Government and Industry Lead the Way in Funding USPSTF Systematic Reviews
- Communication-Based Intervention Increases Goals-of-Care Discussions Between Physicians, Patients With Serious Illness