Clinical Trials

Data Transparency and Publication Bias: Impact on Clinical Trials

Data Transparency and Publication Bias: Impact on Clinical Trials

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The need for data transparency carries an ethical and moral obligation and requires nonselective and unbiased publication of clinical results.

Reducing the <i>P</i>-Value for Statistical Significance to Improve the Quality of Research?

Reducing the P-Value for Statistical Significance to Improve the Quality of Research?

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In a controversial and divisive article, a group of researchers proposes to improve "statistical standards of evidence" by lowering the P value from P <.05 to P <.005 in the fields of biomedical and social sciences.

Cancer-specific Reference Values Specified for PROMIS Domains

Cancer-specific Reference Values Specified for PROMIS Domains

Reference values for PROMIS domains have been established by a population-based study.

Measuring Clinically Meaningful Outcomes in Chronic Pain Clinical Trials

Measuring Clinically Meaningful Outcomes in Chronic Pain Clinical Trials

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Standardized and clinically meaningful outcome measures in clinical trials in chronic pain may enhance efforts to develop effective treatments for chronic pain patients.

Classification of Peripheral Neuropathic Pain Based on Sensory Profiles

Classification of Peripheral Neuropathic Pain Based on Sensory Profiles

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Researchers identified 3 subgroups of patients with peripheral neuropathic pain, based on sensory signs and symptoms.

The Issues With Clinical Studies That Impede the Development of New Pain Drugs

The Issues With Clinical Studies That Impede the Development of New Pain Drugs

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Drug development faces 2 major issues: pre-clinical animal efficacy studies do not accurately predict human efficacy, and clinical trials often wrongly fail to show drug efficacy.

Predicting Placebo Response? It May Now be Possible

Predicting Placebo Response? It May Now be Possible

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Connectivity in the right midfrontal gyrus may help predict placebo response.

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