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Cholestyramine Light
Hyperlipoproteinemias
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Drug Name:

Cholestyramine Light Rx

Generic Name and Formulations:
Cholestyramine resin (as Cl) 4g; per 5g packet or scoop; contains phenylalanine.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Cholestyramine Light:

Hypercholesterolemia alone or with hypertriglyceridemia resistant to dietary management. Reduction in risk of coronary heart disease. Pruritus due to partial biliary obstruction.

Adult:

Initially 1 packet or scoop mixed with fluid or food 1–2 times daily. Maintenance: 2–4 packets or scoops divided into 2 doses; max 6 packets or scoops daily. Increase at 4 week intervals.

Children:

See full labeling.

Contraindications:

Complete biliary obstruction.

Warnings/Precautions:

Obtain baseline serum cholesterol, LDL-C, and triglycerides, and monitor during therapy. May need Vit. A, D, K, and folic acid supplementation with long-term therapy. Exclude secondary causes of hypercholesterolemia (e.g., hypothyroidism, diabetes, nephrotic syndrome, dysproteinemias, obstructive liver disease, alcoholism). Favorable trend in cholesterol reduction usually occurs within 1 month; continue therapy to sustain reduction. Phenylketonuria (Light formulation). Constipation. Hemorrhoids. Pregnancy. Nursing mothers.

Interactions:

Inhibits absorption of phenylbutazone, warfarin, chlorothiazide, propranolol, tetracycline, penicillin G, phenobarbital, thyroid drugs, digitalis, many others; give other drugs 1–2 hours before or 4–6 hours after. Additive effects with HMG-CoA reductase inhibitors, nicotinic acid.

See Also:

Cholestyramine

Pharmacological Class:

Bile acid sequestrant.

Adverse Reactions:

Constipation, fecal impaction, aggravation of hemorrhoids, GI disturbances, osteoporosis, Vit. A, D, K, or folic acid deficiencies, increased bleeding, hyperchloremic acidosis, rash, oral or anal irritation.

Note:

Formerly known under the brand name Questran Light.

How Supplied:

Contact supplier.

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