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Chloramphenicol Inj
Bacterial infections
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Drug Name:

Chloramphenicol Inj Rx

Generic Name and Formulations:
Chloramphenicol sodium succinate 100mg/mL; pwd for IV inj after reconstitution; sodium content 2.25 mEq/g chloramphenicol; preservative-free.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Chloramphenicol Inj:

Serious susceptible infections resistant to other antibiotics. Typhoid fever. Cystic fibrosis regimens.

Adult:

Give by IV inj over ≥1-minute interval. 50mg/kg per day in 4 divided doses every 6 hours. Moderately resistant infections: may increase up to 100mg/kg per day, reduce dose as soon as possible. Typhoid fever: give for 8–10 days after patient has become afebrile. Renal or hepatic impairment: adjust or reduce dose. Switch to oral form as soon as possible.

Children:

Give by IV inj over ≥1-minute interval. Premature, full-term infants <2 weeks old, or children with immature metabolic processes: 25mg/kg per day in 4 divided doses every 6 hours. Children >2 weeks old: up to 50mg/kg per day in 4 divided doses every 6 hours. Severe infections (eg, bacteremia, meningitis): up to 100mg/kg per day, reduce to 50mg/kg per day as soon as possible. Typhoid fever: give for 8–10 days after patient has become afebrile. Switch to oral form as soon as possible.

Contraindications:

Not for trivial infections or prophylaxis. Previous toxic reactions to chloramphenicol.

Warnings/Precautions:

Renal or hepatic impairment. Obtain baseline CBCs then every 2 days during therapy; discontinue if blood dyscrasias, optic neuritis or peripheral neuritis develops. Avoid repeat therapy. Monitor serum levels. Premature and newborn infants. Labor & delivery. Pregnancy. Nursing mothers.

Interactions:

Avoid other bone marrow suppressants.

Pharmacological Class:

Antibiotic.

Adverse Reactions:

Serious/fatal blood dyscrasias, paroxysmal nocturnal hemoglobinemia, GI upset, headache, confusion, delirium, optic and peripheral neuritis, gray baby syndrome, rashes, anaphylaxis, Herxheimer reactions (w. typhoid fever).

Note:

Formerly known under the brand names Chlormycetin, Mychel S.

How Supplied:

Contact supplier.

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