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AZASAN
Arthritis/rheumatic disorders
Organ rejection prophylaxis
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Drug Name:

AZASAN Rx

Generic Name and Formulations:
Azathioprine 75mg, 100mg; scored tabs.

Company:
Valeant Pharmaceuticals, Inc

Therapeutic Use:

Indications for AZASAN:

To reduce signs/symptoms of active rheumatoid arthritis; may be used with aspirin, NSAIDs, and/or low dose corticosteroids.

Adult:

Initially: 1mg/kg (50mg–100mg) daily in 1–2 divided doses; after 6–8 wks, if needed, may increase by 0.5mg/kg daily increments every 4-weeks. Max: 2.5mg/kg per day. Maintenance: use lowest effective dose.

Children:

Not recommended.

Contraindications:

Pregnancy (Cat.D). Prior treatment with alkylating agents (eg, cyclophosphamide, chlorambucil, melphalan, or others) may increase risk of neoplasia.

Warnings/Precautions:

Be fully familiar with product's toxicity before use. Risk of myelotoxicity with low or absent thiopurine S-methyl transferase (TPMT) activity. Monitor blood. Impaired renal function. Discontinue if ineffective after 12 weeks. Nursing mothers: not recommended.

Interactions:

Reduce dose to ⅓ or ¼ with allopurinol. TPMT enzyme inhibition with aminosalicylates (eg, sulphasalazine, mesalazine, olsalazine). Leukopenia with co-trimoxazole. Anemia, leukopenia with ACE Inhibitors. May antagonize warfarin.

Pharmacological Class:

Immunosuppressant.

Adverse Reactions:

Severe leukopenia and/or thrombocytopenia, macrocytic anemia, pancytopenia, severe bone marrow suppression, GI disturbances, secondary infections, mutagenic and carcinogenic potential, hepatotoxicity, rash.

Generic Availability:

YES

How Supplied:

Tabs—100

Indications for AZASAN:

Adjunct for the prevention of rejection in renal homotransplantation.

Adult:

Start at time of transplant or 1–3 days prior; usually with IV formulation. Initially: 3–5 mg/kg daily. Maintenance: 1–3mg/kg daily.

Children:

Not recommended.

Contraindications:

Pregnancy (Cat.D).

Warnings/Precautions:

Be fully familiar with product's toxicity before use; consider discontinuing if severe toxicity occurs. Risk of myelotoxicity with low or absent thiopurine S-methyl transferase (TPMT) activity. Monitor blood. Impaired renal function. Nursing mothers: not recommended.

Interactions:

Reduce dose to ⅓ or ¼ with allopurinol. TPMT enzyme inhibition with aminosalicylates (eg, sulphasalazine, mesalazine, olsalazine). Leukopenia with co-trimoxazole. Anemia, leukopenia with ACE Inhibitors. May antagonize warfarin.

Pharmacological Class:

Immunosuppressant.

Adverse Reactions:

Severe leukopenia and/or thrombocytopenia, macrocytic anemia, pancytopenia, severe bone marrow suppression, GI disturbances, secondary infections, mutagenic and carcinogenic potential, hepatotoxicity, rash.

Generic Availability:

YES

How Supplied:

Tabs—100

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