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AVYCAZ
Bacterial infections
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Drug Name:

AVYCAZ Rx

Generic Name and Formulations:
Ceftazidime 2g, avibactam 0.5g; per vial; pwd for IV inj after reconstitution and dilution; sodium content 6.4mEq/vial.

Company:
Allergan

Therapeutic Use:

Indications for AVYCAZ:

Susceptible infections including complicated intra-abdominal infections (cIAI), in combination with metronidazole, and complicated urinary tract infections (cUTI), including pyelonephritis.

Adult:

Give by IV infusion over 2hrs. ≥18yrs: 2.5g every 8hrs. cIAI: treat for 5–14 days. cUTI: treat for 7–14 days. Renal impairment (CrCl 31–50mL/min): 1.25g every 8hrs; (CrCl 16–30mL/min): 0.94g every 12hrs; (CrCl 6–15mL/min): 0.94g every 24hrs; (CrCl ≤5mL/min): 0.94g every 48hrs; give after hemodialysis on hemodialysis days.

Children:

<18yrs: not established.

Contraindications:

Cephalosporin hypersensitivity.

Warnings/Precautions:

Penicillin or other beta-lactam allergy. Discontinue if allergic reaction occurs. Evaluate and manage fluid, electrolyte levels, supplement protein intake if C.diff-associated diarrhea suspected or confirmed. Renal impairment; monitor CrCl at least daily and adjust dose as necessary. Pregnancy. Nursing mothers.

Interactions:

Concomitant probenecid: not recommended. False (+) urine glucose test possible.

Pharmacological Class:

Cephalosporin + beta-lactamase inhibitor.

Adverse Reactions:

Diarrhea, nausea, vomiting, constipation, anxiety; C.diff-associated diarrhea, hypersensitivity reactions, CNS reactions (eg, seizure, encephalopathy, coma).

Generic Availability:

NO

How Supplied:

Single-use vial—1, 10

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