Generic Name and Formulations:
Amitriptyline HCl 10mg, 25mg, 50mg, 75mg, 100mg, 150mg; tabs.
Various generic manufacturers
- Low-Dose Amitriptyline May Be Effective in Reducing Low Back Pain Intensity and Disability
- Pediatric Migraine: Evidence-Based Alternative Management
- Few Studies on Pharmacotherapies for Postherpetic Neuralgia Report Adverse Events
Indications for Amitriptyline:
Depression especially endogenous.
Initially 75mg daily in divided doses or 50–100mg daily at bedtime; max 150mg daily. Elderly and adolescents: reduce dose.
During or within 14 days of MAOIs. Acute post MI.
History of seizures, urinary retention, glaucoma. Cardiovascular disease. Suicidal tendencies. Surgery. ECT. Psychosis. Hyperthyroidism. Liver dysfunction. Diabetes. Gradually reduce to lowest effective maintenance dose. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
During or within 5 weeks of fluoxetine. Hyperpyretic crises, severe convulsions, and death with MAOIs (see Contraindications). May block guanethidine. Potentiates alcohol, barbiturates, other CNS depressants. Delirium with disulfiram, ethchlorvynol. Paralytic ileus with anticholinergics. Hyperpyrexia with anticholinergics, sympathomimetics. Monitor serum levels with CYP450 inhibitors (eg, quinidine, cimetidine, phenothiazines, propafenone, flecainide, others: see literature).
Drowsiness, anticholinergic effects, CNS overstimulation, arrhythmias, stroke, coma, confusion, extrapyramidal symptoms, hypo- or hypertension, nausea, fatigue, rash, increased perspiration, headache, photosensitivity, edema, blood dyscrasias, alopecia, libido changes, changes in blood sugar; women: breast enlargement, galactorrhea; men: testicular swelling, gynecomastia.
Formerly known under the brand name Elavil.
Clinical Pain Advisor Articles
- Two Screening Tools May Accurately Predict Transition From Acute to Chronic Low Back Pain
- Operant Learning May Provide More Benefits Than Energy Conservation in Fibromyalgia
- Predicting the Magnitude of Placebo Analgesia in Chronic Pain
- Methamphetamine Use on the Rise in Patients With Opioid Use Disorder
- Examining the Efficacy of Different Oxygen Flow Rates for Cluster Headache Attacks
- The Unintended Consequences of the CDC Opioid Guideline According to Pain Management Specialists
- Initial Consultation for Neck Pain May Reduce Opioid Consumption, Healthcare Utilization
- FDA-Approved Test Provides Pharmacogenetic Reports Directly to Consumers
- Set of Interventions May Effectively Reduce Opioid Overprescribing
- Cannabinoid-Associated Analgesia May Be Mediated Through Modulation of Affective Processes
- Half of the Responders to Our Poll Agree With the Approval of Dsuvia: We Want to Hear From You
- Daily Alcohol Use May Drive Chronic Pain in Adults With HIV
- Tools to Address the Opioid Crisis
- AHA/ACC Release Updated Guidelines for Cholesterol Management
- Women Fed Soy Formula as Infants More Likely to Experience Menstrual Pain