Cotargeting of peripheral μ-opioid and cannabinoid receptors was found to have a synergistic effect in reducing mechanical allodynia in a mouse model of neuropathic pain.
Treatment with the capsaicin 8% patch Qutenza may be more effective than pregabalin for reducing the intensity and area of dynamic mechanical allodynia and for complete resolution of the disorder.
Chronic pain experienced by patients with pachyonychia congenita may be caused by damage to the peripheral nerve fibers, with the hyperalgesia and allodynia observed in affected regions likely to be manifestations of peripheral sensitization.
The higher interictal levels of oxytocin observed in patients with chronic migraine compared with unaffected individuals may contribute to the affective component of experimental pain.
Identification of Mechanism Involved in the Maintenance of Pain Behaviors, Mechanical HypersensitivityAugust 02, 2017
The extracellular phosphorylation of EphB2 was shown to maintain pain behaviors and mechanical hypersensitivity after injury.
Symptoms associated with central sensitization are common in children and adolescents with migraine.
The understanding of the mechanisms of allodynia is essential for the treatment of migraine.
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- Capsaicin 8% Patch May Be Effective in Neuropathic Pain
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- Prior Authorization Policy May Help Reduce Long-Acting Opioid Use
- Deaths After Nonfatal Opioid Overdose: Causes and Risk Factors
- Targeted Educational Intervention Helped Reduce Opioid Exposure in Adult Inpatients
- Systematic Cross-Checking May Reduce Medical Errors in Emergency Departments
- Corticosteroid Plus Lidocaine Injections Do Not Alleviate Pain in Central Lumbar Spinal Stenosis
- Tofacitinib May Effectively Alleviate Pain in RA, Psoriatic Arthritis, and Ankylosing Spondylitis