The FDA is not bound by the Committee's recommendation but takes it into consideration when making its decision.
Oliceridine, a G-protein biased mu-opioid receptor (MOR) ligand, has a unique mechanism of action that allows for more selective pathway activation while avoiding a pathway associated with opioid-related adverse events.
Robaxin is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.
The use of a vibrating kinetic anesthesia device may be well-tolerated and effective in reducing pain associated with infiltrative lidocaine injections for biopsy and excisional surgery.
Intravenous hydromorphone may provide greater analgesic effect compared with intravenous acetaminophen in adult patients presenting to the emergency department with severe acute pain.
Pregabalin co-administered with misoprostol was not found to reduce pain intensity in women initiating medical abortion, but was found to be associated with increased satisfaction and reduced use of narcotics and ibuprofen.
Acute postoperative pain scores were found to be associated with chronic opioid use after total knee arthroplasty in patients taking opioid medications prior to intervention.
Virtual reality may effectively alleviate pain and anxiety for unmedicated women experiencing contractions during the first stage of labor.
Consensus guidelines regarding the use of ketamine for the management of acute pain have been approved.
Information on fever-reducing medications including formulation, strength and dosage.
A panel of emergency medicine and pharmacology experts formulated guidelines for safely and effectively treating patients presenting to the emergency department with acute pain.
Researchers conducted a systematic literature review to identify randomized controlled trials comparing 8 different types of foot orthotics.
The use of non-opioid analgesic therapies is increasing among ED physicians.
Investigators sought to determine whether phrenic nerve infiltration and suprascapular nerve block would control acute ipsilateral shoulder pain after thoracotomy.
The FDA has approved Apadaz for the short-term management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.
The most promising tools to predict acute pain after cesarean delivery are local anesthetic infiltration before placement of spinal anesthesia, and asking patients simple questions about anticipated pain and analgesic needs.
Preliminary results suggest that a new sublingual buprenorphine wafer may offer high bioavailability and fast absorption for patients treated for acute and chronic pain.
Acute pain management in the emergency department with low-dose ketamine may provide pain relief comparable with morphine at 30 minutes.
ACTTION Consensus Provides Best Practices for the Design of Pediatric Clinical Trials Focused on Acute PainJanuary 08, 2018
Key factors susceptible to improve the design of clinical trials on analgesics for acute pain in pediatric populations were reviewed and recommendations published.
The most common work-related musculoskeletal disorders in physicians were found to be degenerative cervical spine disease, rotator cuff pathology, degenerative lumbar spine disease, and carpal tunnel syndrome.
Compared to other commonly used opioids, buprenorphine offers a ceiling effect for respiratory depression and less abuse potential, less cognitive impairment, and less constipation.
Nonopioid Analgesic Combination and Opioid Combinations Provide Similar Analgesic Effects for Acute Extremity PainDecember 04, 2017
Nonopioid analgesic combinations may be noninferior to opioid/acetaminophen combinations for reducing acute extremity pain.
Trevena has submitted their New Drug Application to the FDA for Olinvo, an oliceridine injection, for the management of moderate-to-severe pain in the hospital and similar settings.
Opioid treatment of acute postoperative pain was shown to cause high rates of postoperative nausea and vomiting, particularly in women and younger patients.
SoluMatrix indomethacin may represent a treatment option for the management of moderate acute pain, including patients in emergency room settings.
A number of shortcomings are associated with systematic reviews and meta-analyses of postoperative care.
There was a correlation for consistent vitamin D supplementation with increase in physical component of the SF-12 score.
An online tool predicts which patients with chest pain are likely to have normal non-invasive test results and remain free of cardiac adverse events.
Intravenous lidocaine seems safe for reducing pain among patients in the intensive care unit with varying degrees of organ dysfunction.
Opioids prescribed for pain following a motor vehicle collision do not reduce the likelihood of developing persistent pain.
Clinical Pain Advisor Articles
- Chronic Pain May Be a Contributing Factor to Suicide
- Striking a Balance Between Opioid Surveillance and Patient Privacy
- Demographic Characteristics of Pregnant Women With Opioid Use Disorder
- Supervised Injection Sites: Facts, Information, Pros, and Cons
- Effects of Mindfulness Therapy, Pharmacologic Prophylaxis on Catecholamine Levels in Migraine
- Perioperative Pain Management in Patients With Opioid Use Disorder
- Cannabinoid-Associated Analgesia May Be Mediated Through Modulation of Affective Processes
- Antidepressant Effects of Ketamine Appear to Require Opioid System Activation
- Reviewing the Efficacy of Intrathecal Morphine, Ziconotide for Cancer- and Noncancer Chronic Pain
- Seven-Item Pain Intensity Measure Reliable in Individuals With Dementia
- Factors Associated With Suboptimal Interscalene Brachial Plexus Block for Arthroscopy
- Initial Consultation for Neck Pain May Reduce Opioid Consumption, Healthcare Utilization
- Scholarship Support Limited for Veterans Enrolling in MD Programs
- Alpha and Beta Band Activity in MS-Related Chronic Pain
- New Opioid-Induced Constipation Management Guidelines Available