Acute Pain

Low-Dose Ketamine Provides Comparable Acute Pain Relief, More Adverse Events Than Morphine

Low-Dose Ketamine Provides Comparable Acute Pain Relief, More Adverse Events Than Morphine

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Acute pain management in the emergency department with low-dose ketamine may provide pain relief comparable with morphine at 30 minutes.

ACTTION Consensus Provides Best Practices for the Design of Pediatric Clinical Trials Focused on Acute Pain

ACTTION Consensus Provides Best Practices for the Design of Pediatric Clinical Trials Focused on Acute Pain

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Key factors susceptible to improve the design of clinical trials on analgesics for acute pain in pediatric populations were reviewed and recommendations published.

High Prevalence of Musculoskeletal Disorders in At-Risk Physicians

High Prevalence of Musculoskeletal Disorders in At-Risk Physicians

The most common work-related musculoskeletal disorders in physicians were found to be degenerative cervical spine disease, rotator cuff pathology, degenerative lumbar spine disease, and carpal tunnel syndrome.

FDA Accepts New Drug Application for Novel Buprenorphine Sublingual Spray

FDA Accepts New Drug Application for Novel Buprenorphine Sublingual Spray

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Compared to other commonly used opioids, buprenorphine offers a ceiling effect for respiratory depression and less abuse potential, less cognitive impairment, and less constipation.

Nonopioid Analgesic Combination and Opioid Combinations Provide Similar Analgesic Effects for Acute Extremity Pain

Nonopioid Analgesic Combination and Opioid Combinations Provide Similar Analgesic Effects for Acute Extremity Pain

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Nonopioid analgesic combinations may be noninferior to opioid/acetaminophen combinations for reducing acute extremity pain.

New Drug Application Submitted for Olinvo to Treat Acute Pain

New Drug Application Submitted for Olinvo to Treat Acute Pain

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Trevena has submitted their New Drug Application to the FDA for Olinvo, an oliceridine injection, for the management of moderate-to-severe pain in the hospital and similar settings.

Predictors of Nausea, Vomiting in Patients Receiving Postoperative Opioids

Predictors of Nausea, Vomiting in Patients Receiving Postoperative Opioids

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Opioid treatment of acute postoperative pain was shown to cause high rates of postoperative nausea and vomiting, particularly in women and younger patients.

Acute Pain Management in the Emergency Department With SoluMatrix Indomethacin

Acute Pain Management in the Emergency Department With SoluMatrix Indomethacin

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SoluMatrix indomethacin may represent a treatment option for the management of moderate acute pain, including patients in emergency room settings.

Antipyretic Medications

Information on fever-reducing medications including formulation, strength and dosage.

Strategies to Prevent the Transition From Postoperative Acute Pain to Chronic Pain

Strategies to Prevent the Transition From Postoperative Acute Pain to Chronic Pain

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A number of shortcomings are associated with systematic reviews and meta-analyses of postoperative care.

AAOS: Few Hip Fracture Patients Consistently Take Vitamin D

AAOS: Few Hip Fracture Patients Consistently Take Vitamin D

There was a correlation for consistent vitamin D supplementation with increase in physical component of the SF-12 score.

Online Tool To Determine When Tests Are Needed for Chest Pain

Online Tool To Determine When Tests Are Needed for Chest Pain

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An online tool predicts which patients with chest pain are likely to have normal non-invasive test results and remain free of cardiac adverse events.

Lidocaine Safe, Effective for Pain in the ICU

Lidocaine Safe, Effective for Pain in the ICU

Intravenous lidocaine seems safe for reducing pain among patients in the intensive care unit with varying degrees of organ dysfunction.

Opioids vs NSAIDs Following Motor Vehicle Collision

Opioids vs NSAIDs Following Motor Vehicle Collision

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Opioids prescribed for pain following a motor vehicle collision do not reduce the likelihood of developing persistent pain.

Diagnostic Criteria for Chronic Sickle Cell Disease-Related Pain

Diagnostic Criteria for Chronic Sickle Cell Disease-Related Pain

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A new evidence-based classification system for chronic sickle cell disease pain was recently published.

Lidocaine, Not Sucrose, Relieved Some Pain in Infant Vaccination

Lidocaine, Not Sucrose, Relieved Some Pain in Infant Vaccination

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In a comparative study, topical liposomal lidocaine proved most effective for analgesia during infant vaccination.

Pain Control After Nephrectomy: Epidural & Continuous Surgical Site Analgesia

Pain Control After Nephrectomy: Epidural & Continuous Surgical Site Analgesia

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Many patients experience pain months after nephrectomy. Continuous surgical site analgesia may offer the best long-term pain control.

New Tool Measures Stress to Predict Level of Postoperative Pain

New Tool Measures Stress to Predict Level of Postoperative Pain

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Psychological factors may influence the severity and duration of pain following surgery.

Chinese Herb Shows Antinociceptive Effects on Neuropathic Pain

Chinese Herb Shows Antinociceptive Effects on Neuropathic Pain

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YHS presents a potential new treatment option for neuropathic pain management, without the tolerance observed with many analgesic drugs.

Does Massage Therapy Significantly Improve Function in Patients With Post-Surgical Pain?

Does Massage Therapy Significantly Improve Function in Patients With Post-Surgical Pain?

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The researchers concluded that the results from this systematic review and meta-analysis are promising, and that it is worth investing in these recommendations in future research to be able to eventually offer massage therapy to surgical patients experiencing pain.

Nebulized Fentanyl vs. IV Opioids for Acute Pain

Nebulized Fentanyl vs. IV Opioids for Acute Pain

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Nebulized fentanyl is as effective as IV opioids for the treatment of acute pain.

Study to Test Ways To Discuss Opioid Risks With ER Patients

Study to Test Ways To Discuss Opioid Risks With ER Patients

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Researchers hypothesize that communicating opioid addiction risks to patients using real-life narratives could be effective and low-cost.

Removing Pain Questions From Patient Experience of Care Surveys

Removing Pain Questions From Patient Experience of Care Surveys

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Pain management questions from patient satisfaction surveys have been used to influence Medicare reimbursement rates and have resulted in unintended consequences in light of the nation's opioid epidemic.

Medical Marijuana Laws May Reduce Medicare Prescription Use, Spending

Medical Marijuana Laws May Reduce Medicare Prescription Use, Spending

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In states where marijuana is legalized for medicinal purposes, Medicare's prescription drug benefit program has lowered its spending due to reduced prescription drug use.

Age, Inflammation and Transition From Acute to Chronic Pain

Age, Inflammation and Transition From Acute to Chronic Pain

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Caused by dysregulation of inflammatory responses

Phase 3 Trial for Sublingual Sufentanil for the Treatment of Moderate-to-Severe Acute Pain

Phase 3 Trial for Sublingual Sufentanil for the Treatment of Moderate-to-Severe Acute Pain

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ARX-04 would provide a non-invasive option for moderate-to-severe acute pain in medical settings.

Local Infiltrative Anesthesia vs Regional Blockade for Post-TKA Pain

Local Infiltrative Anesthesia vs Regional Blockade for Post-TKA Pain

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In this pooled meta-analysis, LIA provided better analgesia at rest in the immediate post-operative period when compared to RB, in addition to preserving quadriceps function.

Shortages of Acute, Non-Acute Drugs Continues in US

Shortages of Acute, Non-Acute Drugs Continues in US

Despite legislation, there is a longer wait time for vital acute-care medications.

Sleep Problems Persist After Traumatic Brain Injury

Sleep Problems Persist After Traumatic Brain Injury

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Many patients significantly underestimated their daytime sleepiness and sleep need.

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