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ACTHREL
Miscellaneous diagnostic tests
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Drug Name:

ACTHREL Rx

Generic Name and Formulations:
Corticorelin ovine (as the trifluoroacetate) 100mcg/vial; pwd for IV inj after reconstitution.

Company:
Ferring Pharmaceuticals, Inc.

Therapeutic Use:

Indications for ACTHREL:

For use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushings syndrome.

Adults and Children:

Testing pituitary corticotrophin function: 1mcg/kg IV as a single dose. ACTH and cortisol response prolonged and remain elevated for up to 2 hours. Doses >1mcg/kg: not recommended. If repeat test needed, do tests at the same time of day as original test.

Warnings/Precautions:

Higher doses associated with transient tachycardia, decreased BP, loss of consciousness, and asystole; symptoms may be reduced if given as a 30 second IV infusion instead of bolus inj. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Plasma ACTH response inhibited by dexamethasone. Heparin to maintain IV cannula patency: not recommended.

Pharmacological Class:

Corticotropin-releasing hormone (CRH) analogue.

Adverse Reactions:

Flushing of the face, neck, upper chest; tachycardia, hypotension, dyspnea, chest compression or tightness with higher doses.

How Supplied:

Single-dose vial—1

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