Generic Name and Formulations:
Acetylcysteine 200mg/mL; soln for IV infusion after dilution; preservative-free.
Cumberland Pharmaceuticals, Inc.
Indications for ACETADOTE:
To minimize hepatic injury after acetaminophen overdose.
Adults and Children:
Administer within 8 hours for maximal protection against hepatic injury. Estimate time of acetaminophen ingestion. If <24 hours since overdose, obtain serum acetaminophen level 4 hours post-ingestion or as soon as possible thereafter and plot level on nomogram, draw second level 4–6 hours after first; if either falls above toxicity line, initiate therapy. If >8 hours post-ingestion, start treatment immediately. If time of ingestion unknown: consider empiric initiation of treatment. 300mg/kg given as 3 separate doses and administered over a total of 21 hours. See full labeling for preparation based on patient weight. >100kg: loading dose: 15,000mg over 1 hour; first maintenance dose: 5,000mg over 4 hours; second maintenance dose: 10,000mg over 16 hours.
Asthma. History of bronchospasm. Monitor for severe hypersensitivity reactions; may treat with antihistamines and epinephrine; interrupt or discontinue treatment if persistent. Avoid fluid overload esp. in patients <40kg or those requiring fluid restriction; reduce volume of diluent as needed (see full labeling). Monitor liver enzymes, INR, creatinine, BUN, blood glucose, electrolytes. Hepatic or renal impairment: see full labeling. Pregnancy. Nursing mothers (pump and discard milk for 30hrs after therapy).
Hypersensitivity reactions (eg, rash, urticaria/facial flushing, pruritus, edema, hypotension, cough, wheezing, SOB, bronchospasm), GI upset, tachycardia.
Single-use vial (30mL)—4
Clinical Pain Advisor Articles
- Brain Plasticity in Patients With Complex Regional Pain Syndrome
- Chronic Pain Associated With Traumatic Brain Injury: Causes and Management
- Perturbation-Based Rehabilitation Effective for Chronic Low Back Pain
- Migraine Frequency Correlated With Depression and Anxiety
- IBS-Associated Chronic Pain: Formulation of Core Diagnostic Criteria
- Cannabis Use Associated With Aberrant Drug Behaviors
- Walgreens to Carry Naloxone in All Pharmacies to Combat Drug Abuse
- Independent Pharmacies Expanding Services Available to Patients
- Ketamine Exhibits Effective Pain Relief for Refractory Headaches
- Pain In Elite Athletes: IOC Recommendations on Contributing Factors and Treatment Approach
- Naproxen Plus Muscle Relaxants vs Naproxen Monotherapy for Low Back Pain
- Pain Processing: Examining the Role of Oxytocin
- Short- vs Long-Acting Opioids for Osteoarthritis Pain
- Extended-Release Naltrexone Injections Reduce Opioid Dependence
- Depressive Symptoms in Medical Interns Increased With Work-Family Conflicts